NEAT and Insulin Sensitivity
The Effect of Activity on Insulin Sensitivity and Lipid Metabolism in Sedentary, Overweight People.
1 other identifier
interventional
18
1 country
1
Brief Summary
The effect of Non-Exercise Activity Thermogenesis (NEAT) or inactivity on insulin sensitivity and lipid metabolism is unclear. Research recently published shows that activities associated with everyday activities, summarized as NEAT, such as walking and standing, have a much greater role in energy expenditure than exercise. Therefore, the objective of the present study is to evaluate the effect of 4 days of inactivity (mainly sitting), 4 days of everyday activities (sitting, walking and standing), and 4 days of inactivity and exercise (sitting and biking) on glucose metabolism and insulin sensitivity using an oral glucose tolerance test, and on lipid metabolism in sedentary, overweight people. The investigators hypothesize that:
- 1.4 days of everyday activities (NEAT) will cause an increased glucose tolerance and increased insulin sensitivity compared to 4 days of inactivity in sedentary, overweight people.
- 2.4 days of exercise will improve glucose tolerance and insulin sensitivity more than 4 days of NEAT with equal energy expenditure, in sedentary, overweight people.
- 3.Fasting triglyceride will have the same course as glucose, mentioned in 1. and 2.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Dec 2010
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2010
CompletedFirst Submitted
Initial submission to the registry
January 17, 2011
CompletedFirst Posted
Study publicly available on registry
February 18, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2011
CompletedJuly 10, 2012
July 1, 2012
6 months
January 17, 2011
July 9, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change in insulin sensitivity after 4 days of NEAT compared to 4 days of inactivity and compared to 4 days of exercise
Change in insulin sensitivity measured using oral glucose tolerance test
day 5
Secondary Outcomes (1)
Change in fasting triglycerides after 4 days of NEAT compared to 4 days of inactivity and compared to 4 days of exercise
5 day
Study Arms (3)
Inactivity
NO INTERVENTION4 days of inactivity, mainly sitting
NEAT
ACTIVE COMPARATOR4 days of NEAT (everyday activities)
Exercise
ACTIVE COMPARATOR4 days of inactivity combined with 1 hour of exercise
Interventions
4 days of everyday activities, including 4 hours of walking, 8 hours of sitting, 2 hours of standing, 2 hours of everyday activities and 8 hours of sleeping or laying down per day
4 days of activity program, including 1 hour biking (exercise), 13 hours of sitting, 2 hours of everyday activities and 8 hours of sleeping or laying down per day
Eligibility Criteria
You may qualify if:
- Age between 18-30 years old
- BMI between 25.0-30.0 kg/m2
- Sedentary, defined as maximum of exercise of 1 hour/week and less than 2x/week
You may not qualify if:
- Cardiovascular disease
- Diabetes mellitus type 1 or 2 or fasting glucose \> 6.9 mmol/L
- Other diseases that make physical activity difficult
- Alcohol \> 2 consumptions/day
- Illegal drug use and cannabis use
- Medication use, other than contraception
- Triglycerides \> 3.0 mmol/L
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Maastricht University Medical Center/ University of Maastricht
Maastricht, 6202 AZ, Netherlands
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Nicolaas C Schaper, Prof., MD
Maastricht University Medical Center/ University of Maastricht
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 17, 2011
First Posted
February 18, 2011
Study Start
December 1, 2010
Primary Completion
June 1, 2011
Study Completion
July 1, 2011
Last Updated
July 10, 2012
Record last verified: 2012-07