Database of Positon Emission Tomography (PET) Digital Brain Exams, in 50th Age of Patients

NCT04163276 | Completed

• 1 other identifier: 2019PI238
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluate the interest to create a new database of PET digital brain exams in population of 50 years and over of patients. Half of patients with no abnormal brain metabolism while the other half patients with Alzheimer's disease.

Conditions

Neurodegenerative Diseases

Keywords

neurodegenerative disease; digital brain PET exam; database

Outcome Measures

Primary Outcomes (1)

• data base analysis

  Comparison of Z-scores from PET/CT of the quantitative analysis of patients without abnormality of the brain metabolism and of typical Alzheimer patients (brain metabolism of the regions involved in Alzheimer's disease), calculated with 2 databases: * An analogue database consisting of 18F-FDG PET/CT without brain metabolism abnormalities in patients aged 50 and over; * A digital database, consisting of 18F-FDG PET/CT without brain metabolism abnormalities in patients aged 50 and over

  1 hour

Study Arms (2)

Group 1

20 patients without anomaly of brain metabolism

Diagnostic Test: 18F FDG PET exam

Group 2

20 patients with Alzheimer's disease

Diagnostic Test: 18F FDG PET exam

Interventions

18F FDG PET exam DIAGNOSTIC_TEST

All patients have received 18F-FDG PET/CT in nuclear medicine

Group 1; Group 2

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The population will be enrolled thank to a listing of patient available in nuclear médicine unit. This listing cntain patient who performed a 18F-FDG brain TEP in nuclear médicine unit between 2010 and 2019.

You may qualify if:

• Having performed a 18F-FDG cerebral PET/CT exam as part of an Alzheimer's assessment at the Nuclear Medicine department of NANCY, sent by the Geriatric Department
• Patient who has received complete information on the organization of the research and who has not objected to the exploitation of this data
• Patient affiliated to a social security

You may not qualify if:

• patient who has received complete information on the organization of the research and who has objected to the exploitation of this data
• For patients with no abnormality in 18F-FDG PET, Mini Mental State Examination (MMSE) \<25 or clinically diagnosed neurodegenerative pathology
• For patients with typical hypometabolism of 18F-FDG PET/CT, biology of cerebrospinal fluid not in favor of Alzheimer's disease

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead
• GIE NANCYCLOTEP: collaborator

Study Sites (1)

University hospital of Nancy

Vandœuvre-lès-Nancy, 54511, France

Location

MeSH Terms

Conditions

Neurodegenerative Diseases

Condition Hierarchy (Ancestors)

Nervous System Diseases

Study Officials

• Verger Antoine, PhD

  Central Hospital, Nancy, France

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 12, 2019
• First Posted: November 14, 2019
• Study Start: January 2, 2008
• Primary Completion: June 6, 2020
• Study Completion: October 1, 2020
• Last Updated: November 27, 2020

Record last verified: 2020-11

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)