NCT01275040

Brief Summary

A pragmatic cluster randomised controlled trial will be done where the intervention will be a mobile screening team visiting selected PHC facilities in Tshwane district. It will provide education and screening for diabetic complications (foot, kidney, cardiac and retinal complications). Six clinics will receive the intervention and six clinics will serve as controls. Six hundred patients will be recruited (2 x 300). The screening results will be evaluated by an expert panel at tertiary care level and an individualised patient management plan will be compiled. This plan will be communicated to the family physician and integration team at the clinic for further management or referral of the patients. Laser therapy will be available on the mobile clinic for patients that require it (as assessed by an Ophthalmologist who will review the retinal photos). A baseline evaluation (including HbA1c, serum creatinine, lipogram and urine albumin-creatinine ratio) will be done to determine current disease management at patient and health facility level, followed by the intervention and a follow-up visit a year later. The main outcome measures are glucose, lipid and blood pressure control as well as the percentage of patients screened and referred for diabetes complications. A cost effectiveness analysis will be done to estimate the added cost per added complication prevented or referred. The potential implications for improving diabetes care and preventing long term complications are extremely important. The study results will be used to help plan future health care services for people with diabetes mellitus in the region.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
600

participants targeted

Target at P75+ for not_applicable diabetes

Timeline
Completed

Started Jun 2010

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2010

Completed
6 days until next milestone

First Submitted

Initial submission to the registry

June 7, 2010

Completed
7 months until next milestone

First Posted

Study publicly available on registry

January 12, 2011

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2012

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2012

Completed
Last Updated

March 24, 2011

Status Verified

March 1, 2011

Enrollment Period

1.8 years

First QC Date

June 7, 2010

Last Update Submit

March 23, 2011

Conditions

Keywords

diabetesmobile screeningcomplicationsprimary carespecialised carequality of care

Outcome Measures

Primary Outcomes (4)

  • Change in HbA1c values between year 1 and year 2

    2 Years

  • Descriptive demographics of participants

    1 Year

  • Between group differences in patients with detected neuropathy, nephropathy and retinopathy

    2 Years

  • Between group differences in HbA1c categories

    1 year

Secondary Outcomes (6)

  • Between group differences in complications detected

    2 Years

  • Between group differences in referred patients for complication assessment or care

    1 Year

  • Between group differences in blood pressure and lipid control

    1 Year

  • To cost the intervention and evaluate additional costs per complication detected

    1 Year

  • Collection of cross sectional data regarding complications and metabolic control from patients not enrolled in the trial but who are attending screening visits by the mobile team

    1 Year

  • +1 more secondary outcomes

Study Arms (2)

Mobile screening team

EXPERIMENTAL

The Primary Health Care clinics where the mobile screening team will visit and active screening for DM complications will take place.

Other: Mobile screening; Health Education

No mobile screening team

ACTIVE COMPARATOR

No mobile team will visit clinics and active screening for DM complications will not be done. Patients and Health Workers will receive Education, same as intervention arm but no enhanced care.

Other: Health education

Interventions

Active screening for diabetes complications - neuropathy screening, retinopathy screening, blood and urine tests. Health education for both patients and health workers on diabetes. Active collaboration between primary and tertiary care in the public health system.

Mobile screening team

Health education given to both patients and healthcare workers. No mobile screening team will visit facilities and no interaction between primary and tertiary care will be evaluated.

No mobile screening team

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Clinical diagnosis of diabetes
  • All type 2 diabetics and type 1 diabetics with minimum of 5 years duration
  • Above 18 years of age

You may not qualify if:

  • Diabetics below 18 years of age
  • Type 1 diabetics with duration of disease less than 5 years

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

School of Health Systems and Public Health, University of Pretoria

Pretoria, Gauteng, 0001, South Africa

Location

Related Links

MeSH Terms

Conditions

Diabetes Mellitus

Condition Hierarchy (Ancestors)

Glucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Officials

  • Paul Rheeder, PhD

    School of Health Systems and Public Health, University of Pretoria, South Africa

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

June 7, 2010

First Posted

January 12, 2011

Study Start

June 1, 2010

Primary Completion

March 1, 2012

Study Completion

May 1, 2012

Last Updated

March 24, 2011

Record last verified: 2011-03

Locations