Study of the Fixation of Various Vectors in PET/CT in Patients With a With Lung Cancer Before and During of CRT or RT

NCT01261585 | Completed DMC

• 1 other identifier: CHB 08-01
• Study Type: observational
• Target: 5
• Locations: 1 country
• Sites: 1

Brief Summary

Study of the modification of the fixation(binding) of Fluoro-2-deoxy-D-glucose (FDG), fluoro-misonidazole (FMISO) and 3'deoxy-3-fluoro-thymidine deoxy-3-fluoro-thymidine (FLT) measured in tomography by broadcast(emission,issue) of positrons (PET) at patients before and in the course of exclusive radiotherapy or concomitant radiochemotherapy for primitive bronchial cancer. This protocle allows to study the simultaneous variations of the metabolism, the hypoxie and the cellular proliferation by PET SCAN at 5 patients reached(affected) by a primitive bronchial cancer in the course of exclusive radiotherapy for primitive bronchial cancer not small cell lung. The investigators are also going to study several scenarii of optimization of the radiotherapy according to the variations of the tumoral metabolism, the hypoxie and the cellular proliferation measured in the course of radiotherapy (theoretical study on console using the scanner and the various examinations).

Conditions

Bronchial Neoplasms; Carcinoma, Non-Small-Cell Lung

Keywords

Positron-Emission Tomography; PET Scan; FDG; FLT; FMISO; Non-Small-Cell Lung Carcinoma; chemo-Radiation Oncology; SUV

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Diagnosed patients with non-small-cell lung carcinoma

You may qualify if:

• patients with non-small-cell lung carcinoma hitologicaly proved
• Candidate patients in a treatment with aim guardian by exclusive thoracic radiotherapy or of concomitant radiochemotherapy (tumoral dose superior to 60 Gy) ( n=5 ).
• Measurable tumor according to the criteria of evaluation RECIST

You may not qualify if:

• Histology other one than primitive bronchial cancer not in small cells lung
• The patients for whom no tumoral target is assessable (forgiveness completes after first chemotherapy, operated patients).
• Patients for whom a radiotherapy with curative aim is not indicated (tumoral extension, metastases, general state, co-morbidity).
• Patient having benefited from an examination PET in the FDG with in more than 4 weeks and for which a new PET in the FDG is not necessary with in the framework of its disease

Sponsors & Collaborators

• Centre Henri Becquerel: lead

Study Sites (1)

Centre Henri Becquerel

Rouen, Hate Normandie, 76000, France

Location

Related Publications (2)

• Ganem J, Thureau S, Gardin I, Modzelewski R, Hapdey S, Vera P. Delineation of lung cancer with FDG PET/CT during radiation therapy. Radiat Oncol. 2018 Nov 12;13(1):219. doi: 10.1186/s13014-018-1163-2.

  PMID: 30419929 DERIVED

• Calais J, Thureau S, Dubray B, Modzelewski R, Thiberville L, Gardin I, Vera P. Areas of high 18F-FDG uptake on preradiotherapy PET/CT identify preferential sites of local relapse after chemoradiotherapy for non-small cell lung cancer. J Nucl Med. 2015 Feb;56(2):196-203. doi: 10.2967/jnumed.114.144253. Epub 2015 Jan 8.

  PMID: 25572091 DERIVED

MeSH Terms

Conditions

Bronchial Neoplasms; Carcinoma, Non-Small-Cell Lung

Condition Hierarchy (Ancestors)

Lung Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Bronchial Diseases; Respiratory Tract Diseases; Carcinoma, Bronchogenic; Lung Diseases

Study Officials

• GUERNOU Mohamed, MD

  CHBecquerel

  PRINCIPAL INVESTIGATOR

• VERA Pierre, MD phD

  CHBecquerel

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: December 15, 2010
• First Posted: December 16, 2010
• Study Start: December 1, 2008
• Primary Completion: November 1, 2009
• Study Completion: December 1, 2009
• Last Updated: December 16, 2010

Record last verified: 2009-01

Locations

FR (1)