NCT01256957

Brief Summary

The purpose of this study is to evaluate the ability of portable high efficiency particle air (HEPA) filters to reduce exposures to PM2.5 and woodsmoke air pollution indoors and to improve subclinical indicators of microvascular function, systemic inflammation, and oxidative stress among healthy adult participants.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
56

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Nov 2008

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2008

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2009

Completed
1.7 years until next milestone

First Submitted

Initial submission to the registry

December 8, 2010

Completed
1 day until next milestone

First Posted

Study publicly available on registry

December 9, 2010

Completed
Last Updated

December 5, 2016

Status Verified

December 1, 2010

Enrollment Period

5 months

First QC Date

December 8, 2010

Last Update Submit

December 1, 2016

Conditions

Endothelial FunctionOxidative StressSystemic Inflammation

Outcome Measures

Primary Outcomes (1)

  • Reactive hyperemia index

    After 1 week of air filtration

Secondary Outcomes (1)

  • C-reactive protein

    After 1 week of filtration

Study Arms (2)

Indoor air HEPA filtration

ACTIVE COMPARATOR

HEPA filters operating in the participant's bedroom and living room.

Device: HEPA filter

Control

NO INTERVENTION

Control

Interventions

HEPA filterDEVICE
Also known as: Honeywell model 50300, Honeywell model 18150
Indoor air HEPA filtration

Eligibility Criteria

Age19 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • years or older
  • Non-smoking household
  • Lives in study region (Smithers or Telkwa British Columbia)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Simon Fraser University

Burnaby, British Columbia, V5A 1S6, Canada

Location

Related Publications (1)

  • Allen RW, Carlsten C, Karlen B, Leckie S, van Eeden S, Vedal S, Wong I, Brauer M. An air filter intervention study of endothelial function among healthy adults in a woodsmoke-impacted community. Am J Respir Crit Care Med. 2011 May 1;183(9):1222-30. doi: 10.1164/rccm.201010-1572OC. Epub 2011 Jan 21.

    PMID: 21257787DERIVED

Study Officials

  • Ryan Allen, PhD

    Simon Fraser University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
PREVENTION
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

December 8, 2010

First Posted

December 9, 2010

Study Start

November 1, 2008

Primary Completion

April 1, 2009

Study Completion

April 1, 2009

Last Updated

December 5, 2016

Record last verified: 2010-12

Locations

CA(1)