NCT01255748

Brief Summary

The purpose of this research study is to collect and analyze information from patients being treated with various forms of radiation therapy.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
40,000

participants targeted

Target at P75+ for all trials

Geographic Reach
1 country

29 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2009

Completed
1.5 years until next milestone

First Submitted

Initial submission to the registry

December 6, 2010

Completed
1 day until next milestone

First Posted

Study publicly available on registry

December 7, 2010

Completed
28.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2039

Expected
Last Updated

September 9, 2025

Status Verified

September 1, 2025

Enrollment Period

30 years

First QC Date

December 6, 2010

Last Update Submit

September 2, 2025

Conditions

Keywords

cancer, proton, radiation

Outcome Measures

Primary Outcomes (1)

  • Define outcomes for patients treated at participating institutions

    PRN

Secondary Outcomes (2)

  • Determine strategies necessary to improve patients outcome and decrease toxicities related to treatments and procedures

    Annually PRN

  • Improve patient care by an adequate understanding of the results and patient population at participating institutions

    Reviewed Annually PRN

Study Arms (1)

Treatment with Radiation Therapy

Includes 16 different arms to capture patient data by disease site

Radiation: Proton Therapy, Photon Therapy, SRS, Brachytherapy

Interventions

Outcomes Tracking

Treatment with Radiation Therapy

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Radiation Oncology patients

You may qualify if:

  • Planned treatment with radiation therapy
  • Ability to understand and sign IRB approved consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (29)

Mayo Clinic

Scottsdale, Arizona, 85259-5499, United States

RECRUITING

Proton Center of Arkansas

Little Rock, Arkansas, 72205, United States

RECRUITING

California Protons Cancer Therapy Center

San Diego, California, 92121, United States

RECRUITING

South Florida Proton Therapy Institute

Delray Beach, Florida, 33484, United States

RECRUITING

Ackerman Cancer Center

Jacksonville, Florida, 32223, United States

RECRUITING

Dwoskin Proton Therapy Center

Miami, Florida, 33125, United States

RECRUITING

Miami Cancer Institute

Miami, Florida, 33176, United States

RECRUITING

Orlando Health Cancer Institute

Orlando, Florida, 32806, United States

RECRUITING

Emory Proton Therapy Center

Atlanta, Georgia, 30308, United States

RECRUITING

OSF HealthCare Cancer Institute

Peoria, Illinois, 61603, United States

RECRUITING

Northwestern Medicine Chicago Proton Center

Warrenville, Illinois, 60555, United States

RECRUITING

University of Kansas Proton Therapy Center

Kansas City, Kansas, 66160, United States

RECRUITING

Kansas City Proton Institute

Overland Park, Kansas, 66207, United States

RECRUITING

Willis-Knighton Cancer and Proton Therapy Center

Shreveport, Louisiana, 71103, United States

RECRUITING

Maryland Proton Treatment Center

Baltimore, Maryland, 21201, United States

RECRUITING

McLaren Proton Therapy Center

Flint, Michigan, 48532, United States

RECRUITING

Washington University in St. Louis

St Louis, Missouri, 63110, United States

RECRUITING

Mercy David C. Pratt Cancer Center

St Louis, Missouri, 63141, United States

RECRUITING

ProCure Proton Therapy Center

Somerset, New Jersey, 08873, United States

RECRUITING

New York Proton Center

New York, New York, 10035, United States

RECRUITING

Atrium Health Levine Cancer Proton & Advanced Radiation Center

Charlotte, North Carolina, 28204, United States

RECRUITING

University of Cincinnati Medical Center

Cincinnati, Ohio, 45044, United States

RECRUITING

Oklahoma Proton Center

Oklahoma City, Oklahoma, 73142, United States

RECRUITING

Tennessee Oncology Proton Center

Franklin, Tennessee, 37067, United States

RECRUITING

Thompson Proton Center

Knoxville, Tennessee, 37909, United States

RECRUITING

Texas Center for Proton Therapy

Irving, Texas, 75063, United States

RECRUITING

Inova Schar Cancer Institute

Fairfax, Virginia, 22031, United States

RECRUITING

Hampton University Proton Therapy Institute

Hampton, Virginia, 23666, United States

RECRUITING

University of Washington

Seattle, Washington, 98195-6043, United States

RECRUITING

Related Publications (1)

  • Lee HJ Jr, Macomber MW, Spraker MB, Bowen SR, Hippe DS, Fung A, Russell KJ, Laramore GE, Rengan R, Liao J, Apisarnthanarax S, Zeng J. Early toxicity and patient reported quality-of-life in patients receiving proton therapy for localized prostate cancer: a single institutional review of prospectively recorded outcomes. Radiat Oncol. 2018 Sep 17;13(1):179. doi: 10.1186/s13014-018-1127-6.

Related Links

MeSH Terms

Conditions

Neoplasms

Interventions

Proton TherapySpermine SynthaseBrachytherapy

Intervention Hierarchy (Ancestors)

Heavy Ion RadiotherapyRadiotherapyTherapeuticsAlkyl and Aryl TransferasesTransferasesEnzymesEnzymes and Coenzymes

Study Officials

  • Carlos Vargas, MD

    Proton Collaborative Group

    STUDY CHAIR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
30 Years
Sponsor Type
NETWORK
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 6, 2010

First Posted

December 7, 2010

Study Start

June 1, 2009

Primary Completion (Estimated)

June 1, 2039

Last Updated

September 9, 2025

Record last verified: 2025-09

Locations