Effect of Low Glycemic Index Diet on Body Composition and Mechanism of Obese Women

NCT01255228 | Unknown

• 1 other identifier: 99055
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Excessive body weight and obesity have reached epidemic proportions over the last few decades, which may cause many chronic diseases. Maintaining a healthy life style could decrease the risk for obesity, metabolic syndrome and cardiovascular disease. The study aimed to evaluate long-term low glycemic index (GI) diet intervention on lipid profile, body composition and the mechanism of obese women. The pilot study will recruit twenty healthy subjects, and served test food to determine low GI food. In the experiment period, twenty women age from 20-50 years will be recruited. To be included in the study, subjects should have a BMI above 24 kg/m2, or the either one (fat mass ≧ 30% or waistline \> 80 cm). Before dietary intervention, participants will receive food choice table and dietary questionnaires to record their dietary intake. The study will be a randomized, crossover, controlled clinical trails. The experiment period have six weeks, each participants will provide low GI diet (lunch and dinner). On the 0, 3, 6 week, subjects will measurement their body composition (body weight, body mass, waist and hip circumferences) and collect fasting blood samples to analysis the lipid profile, free fatty acid, blood sugar, insulin, adiponectin, leptin and fatty acid synthesis enzymes. Statistical analysis will be performed by paired t-test. The study expect that long-term low GI diet intervention have beneficial effects on regulate body composition of obese women.

Conditions

Obesity

Keywords

obesity; body composition; adipocyte-derived cytokine; low glycemic index

Outcome Measures

Primary Outcomes (1)

• the effect of body composition ( body weight,body mass,waist and hip circumferences )

  6 week

Study Arms (2)

Low glycemic index diet

EXPERIMENTAL

The study expect that long-term low GI diet intervention have beneficial effects on regulate body composition of obese women

Other: Low glycemic index diet

diet intervention

EXPERIMENTAL

The study expect that long-term low GI diet intervention have beneficial effects on regulate body composition of obese women

Other: Low glycemic index diet

Interventions

Low glycemic index diet OTHER

The study expect that long-term low GI diet intervention have beneficial effects on regulate body composition of obese women

Low glycemic index diet; diet intervention

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• BMI above 24 kg/m2, or the either one ( fat mass ≧ 30% or waistline \> 80 cm )

You may not qualify if:

• Cardiovascular disease
• type 2 diabetes mellitus or impaired glucose tolerance
• serious liver or renal disease, gastro-intestinal disease
• proceed serious diet control for formerly three months
• take any supplemental food products or medications known to influence lipid or carbohydrate metabolism

Sponsors & Collaborators

• Taipei Medical University WanFang Hospital: lead

Study Sites (1)

Taipei Medical University

Taipei, Taiwan

Location

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Jen-Fang Liu

  Taipei Medical University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: November 18, 2010
• First Posted: December 7, 2010
• Study Start: May 1, 2010
• Primary Completion: February 1, 2011
• Study Completion: April 1, 2011
• Last Updated: December 7, 2010

Record last verified: 2010-12

Locations

TW (1)