The Role of Respiratory Viruses in Exacerbations of Cystic Fibrosis in Adults

NCT01238081 | Completed

• 1 other identifier: 2010CF004
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Respiratory viruses, such as those that cause colds and influenza, are very common in the general population. The average adult will experience between 2 and 4 viral respiratory illnesses each year. It is known that respiratory viruses can cause flare-ups of chronic lung diseases such as asthma and chronic obstructive pulmonary disease. In children with CF, respiratory viral infections have been identified in nearly half of all exacerbations and are associated with a decline in lung function and increased frequency of hospital admission and acquisition of new bacterial pathogens. Currently, little is known about the impact of viral infections on the course of CF lung disease in adults and no large-scale prospective studies in this area have been performed to date. It is unknown how often respiratory viruses can be found in patients with CF when they are well and what consequences they have on the course of exacerbations of CF lung disease. This study will identify the frequency of common viral infections in adults with CF and determine the effects they have on lung function, the rate and diversity of bacterial infection and patients' treatment burden. The information gained from this study will lead to improved prevention and treatment of respiratory infections in CF.

Conditions

Cystic Fibrosis

Keywords

Cystic fibrosis

Outcome Measures

Primary Outcomes (1)

• Identification of respiratory viruses in sputum, nose- or throat-swabs

  A panel of 6 viruses will be tested for using polymerase chain reaction (PCR)technology: adenovirus, rhinovirus, metapneumovirus, parainfluenza virus 1-3, influenza A,B\&C and respiratory syncytial virus

  12 months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults with cystic fibrosis attending the Manchester Adult Cystic Fibrosis Centre, Manchester, UK

You may qualify if:

• Patients with cystic fibrosis attending Manchester Adult CF Centre
• Age ≥18 years
• Capable of providing written informed consent
• Able and willing to provide required samples and meet visit schedule

You may not qualify if:

• Previous lung transplantation

Sponsors & Collaborators

• Manchester University NHS Foundation Trust: lead

Study Sites (1)

University Hospital of South Manchester NHS Foundation Trust

Manchester, Lancashire, M23 9LT, United Kingdom

Location

Related Links

• UK Cystic Fibrosis Trust
• University Hospital of South Manchester

Biospecimen

Retention: SAMPLES WITHOUT DNA

Serum

MeSH Terms

Conditions

Cystic Fibrosis

Condition Hierarchy (Ancestors)

Pancreatic Diseases; Digestive System Diseases; Lung Diseases; Respiratory Tract Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Infant, Newborn, Diseases

Study Officials

• William G Flight, MBChB

  University Hospital of South Manchester NHS FoundationTrust

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 9, 2010
• First Posted: November 10, 2010
• Study Start: December 1, 2010
• Primary Completion: April 1, 2012
• Study Completion: April 1, 2012
• Last Updated: June 1, 2012

Record last verified: 2012-05

Locations

GB (1)