MR INFORM - a Randomized Non-inferiority Multicenter Trial Comparing MR Perfusion Imaging and Fractional Flow Reserve (FFR) to Guide Management of Patients With Stable Coronary Artery Disease
Sponsor study identifier
interventional
915
1 country
1
Study Start
December 2010
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
August 2016
Actual (reported)Study Completion
December 2016
Actual (reported)The purpose of this study is to determine if MR Perfusion Imaging is non-inferior to coronary angiography with measurement of Fractional Flow Reserve (FFR) in guiding management of patients with stable chest pain.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2016
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 8, 2010
Actual (reported)November 9, 2010
Actual (reported)December 2010
Date type not reportedThis date has not been verified as actual or estimated.
August 2016
Actual (reported)December 2016
Actual (reported)Occurence of major adverse cardiac events (MACE)
Composite of all cause death, myocardial infarction and repeat revascularisation.
1year
Individual MACE
1 year
Other adverse events
1 year
Course of symptoms (angina, breathlessness)
Management guided by the result of the MR perfusion scan. Possible intervention: coronary artery revascularization.
Management guided by the result of FFR measurement. Possible intervention: coronary artery revascularization.
Coronary revascularization guided by MR perfusion imaging
Coronary revascularization guided by invasive angiography and FFR
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
King's College
London, SE1 7EH, United Kingdom
Hussain ST, Paul M, Plein S, McCann GP, Shah AM, Marber MS, Chiribiri A, Morton G, Redwood S, MacCarthy P, Schuster A, Ishida M, Westwood MA, Perera D, Nagel E. Design and rationale of the MR-INFORM study: stress perfusion cardiovascular magnetic resonance imaging to guide the management of patients with stable coronary artery disease. J Cardiovasc Magn Reson. 2012 Sep 19;14(1):65. doi: 10.1186/1532-429X-14-65.
Nagel E, Berry C. Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary Disease. Reply. N Engl J Med. 2019 Dec 5;381(23):2277-2278. doi: 10.1056/NEJMc1913968. No abstract available.
Eike Nagel, MD, PhD
Goethe University Frankfurt
915 participants (actual enrollment reported by the registry).
First Submitted
November 8, 2010
First Posted
November 9, 2010
Study Start
December 2010
Date type not reportedThis date has not been verified as actual or estimated.
Comparative Effectiveness of Decision Aids for Stable Chest Discomfort
1 year
Cost comparison
1 year
changes in LV volumes and function
1 year
Contact the study team to confirm eligibility.
Nagel E, Greenwood JP, McCann GP, Bettencourt N, Shah AM, Hussain ST, Perera D, Plein S, Bucciarelli-Ducci C, Paul M, Westwood MA, Marber M, Richter WS, Puntmann VO, Schwenke C, Schulz-Menger J, Das R, Wong J, Hausenloy DJ, Steen H, Berry C; MR-INFORM Investigators. Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary Disease. N Engl J Med. 2019 Jun 20;380(25):2418-2428. doi: 10.1056/NEJMoa1716734.
Primary Completion
August 2016
Actual (reported)Study Completion
December 2016
Actual (reported)Last Updated
June 24, 2022
Record last verified: 2022-06
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: