Disability and Self-rated Health Following Primary Knee Replacement
The Effects of Primary Knee Replacement for Osteoarthritis on Disability in Activities of Daily Living and Self-rated Health in Older People
1 other identifier
observational
460
1 country
1
Brief Summary
Knee replacement is an effective treatment in late-stage osteoarthritis. It reduces pain and improves quality of life. There is, however, limited data concerning its results in older people and on its effect on how patients survive in regular activities of daily living (ADL), such as bathing and shopping. In this study, the results of knee replacement are evaluated from the point of view of disability in everyday activities and self-rated health. Moreover, association with ADL performance and clinical knee scores and severity of osteoarthritis are assessed.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Dec 2009
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2009
CompletedFirst Submitted
Initial submission to the registry
December 22, 2009
CompletedFirst Posted
Study publicly available on registry
November 9, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 30, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2015
CompletedOctober 18, 2023
October 1, 2023
4 years
December 22, 2009
October 17, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Disability in activities of daily living
Baseline (recruitment) and at 12 months
Secondary Outcomes (2)
Overall self-rated health
Baseline (recruitment) and at 12 months
Health-related quality of life (WOMAC)
Baseline and 12 months postoperatively
Study Arms (1)
Knee replacement recipients
Patients (aged 75 years or over) with late-stage arthritis who have undergone or are undergoing primary knee replacement
Eligibility Criteria
Patients refererred to or operated on with primary knee replacement in a population-based tertiary care hospital
You may qualify if:
- age 75 years or more at the time of operation
- diagnosis of knee osteoarthritis
- scheduled for or operated on with primary knee replacement
You may not qualify if:
- died during the follow-up
- inflammatory arthritides
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Coxa, Hospital for Joint Replacementlead
- Tampere Universitycollaborator
Study Sites (1)
Coxa, Hospital for Joint Replacement
Tampere, 33101, Finland
Related Publications (2)
Limnell K, Jamsen E, Huhtala H, Jantti P, Puolakka T, Jylha M. Functional ability, mobility, and pain before and after knee replacement in patients aged 75 and older: a cross-sectional study. Aging Clin Exp Res. 2012 Dec;24(6):699-706. doi: 10.3275/8718. Epub 2012 Nov 12.
PMID: 23147559RESULTVekama L, Puolakka T, Honkasalo M, Huhtala H, Moilanen T, Jamsen E. Functional gain following knee replacement in patients aged 75 and older: a prospective follow-up study. Aging Clin Exp Res. 2015 Dec;27(6):865-76. doi: 10.1007/s40520-015-0348-x. Epub 2015 Mar 24.
PMID: 25800623RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Esa Jämsen, MD, PhD
Coxa, Hospital for Joint Replacement
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD, PhD, Researcher
Study Record Dates
First Submitted
December 22, 2009
First Posted
November 9, 2010
Study Start
December 1, 2009
Primary Completion
November 30, 2013
Study Completion
December 31, 2015
Last Updated
October 18, 2023
Record last verified: 2023-10