Progressive Exercise After Total Knee Arthroplasty (TKA)
2 other identifiers
interventional
120
1 country
1
Brief Summary
Total knee arthroplasty (TKA) is performed more than 7.000 times a year in Finland most often for osteoarthritis (OA). While pain is predictably reduced, function does not typically ever reach that of age-matched, uninjured subjects. Quadriceps weakness has been implicated in the development and progression of knee OA and is a significant problem after TKA. Advance to return to normal daily activities is not sufficient to restore knee function or quadriceps strength after TKA. The aim of this study is to assess the effectiveness of progressive exercise program restoring knee strength, mobility and improving the functional outcome after primary TKA.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Jan 2008
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2008
CompletedFirst Submitted
Initial submission to the registry
January 16, 2008
CompletedFirst Posted
Study publicly available on registry
January 30, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2012
CompletedMarch 5, 2013
March 1, 2013
2.9 years
January 16, 2008
March 4, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Functional tests, pain
Timed-Up and Go-test, Visual analogue scale (VAS)
baseline , 6 weeks after operation (start of training), after 12 months training
Secondary Outcomes (3)
Knee muscle strength
baseline, 6 weeks after operation (start of training), after 12 months training
Health related quality of life
baseline and 12 months
gait analysis
baseline, 6 weeks postoperatively, 12 months
Study Arms (2)
exercise
EXPERIMENTALprogressive exercise, home-based exercise program, tree exercise sessions weekly, chec-up visits every third month
Conventional treatment
ACTIVE COMPARATORNormal treatment, single guidance to home exercise
Interventions
Home exercises three times a week, control every three months
Eligibility Criteria
You may qualify if:
- primary unilateral TKA for knee osteoarthritis
You may not qualify if:
- Rheumatoid arthritis
- Fibromyalgia
- Bilateral TKA
- Heart or lung disease, which prevent training
- Unstable serious disease (cancer)
- Reduced cooperation (drug, alcohol abuse, mental illness)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Ceneral Finland Health Care District
Jyväskylä, FIN-40620, Finland
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Jari Ylinen, MD, PhD
Central Finland Health Care District
- STUDY CHAIR
Arja Häkkinen, PhD, Professor
Central Finland Health Care District
- PRINCIPAL INVESTIGATOR
Petri Salo, M.Sc.
Central Finland Health Care District
- PRINCIPAL INVESTIGATOR
Mirja Vuorenmaa, M.Sc.
Central Finland Health Care District
- STUDY CHAIR
Maija Pesola, MD
Central Finland Health Care District
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- physiotherapist
Study Record Dates
First Submitted
January 16, 2008
First Posted
January 30, 2008
Study Start
January 1, 2008
Primary Completion
December 1, 2010
Study Completion
December 1, 2012
Last Updated
March 5, 2013
Record last verified: 2013-03