Comprehensive Strategy to Decolonize Methicillin-resistant Staphylococcus Aureus (MRSA) in the Outpatient Setting
1 other identifier
interventional
15
1 country
1
Brief Summary
The purpose of this study is to determine the effectiveness of topical and oral antibiotics in eliminating carriage of methicillin-resistant Staphylococcus aureus (MRSA) among those living in the community. We hypothesize that a greater proportion of those who receive intervention will eliminate MRSA carriage compared to those who do not receive any intervention.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jul 2010
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2010
CompletedFirst Submitted
Initial submission to the registry
November 1, 2010
CompletedFirst Posted
Study publicly available on registry
November 2, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2012
CompletedFebruary 15, 2013
February 1, 2013
1.8 years
November 1, 2010
February 14, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Eradication of MRSA carriage
90 days after randomization
Secondary Outcomes (1)
Occurrence of MRSA infection
Within 6 months of randomization
Study Arms (2)
decolonization treatment
ACTIVE COMPARATORtopical antiseptic, intranasal antimicrobial, and oral antimicrobial that have activity against MRSA in addition to education regarding personal hygiene and environmental cleaning
education
OTHERNo decolonization treatment in addition to education regarding personal hygiene and environmental cleaning
Interventions
Chlorhexidine gluconate 4% body scrub and 2% shampoo daily PLUS mupirocin 2%, fusidic acid 2%, or chlorhexidine gluconate 0.2% intranasally bid PLUS trimethoprim-sulfamethoxazole 160/800mg po bid or doxycycline 100mg po bid all for 7 days
No pharmacological decolonization treatment but given education regarding personal hygiene and environmental cleaning
Eligibility Criteria
You may qualify if:
- Prior MRSA infection (i.e index case)
- Identified as being colonized with MRSA on initial screen
You may not qualify if:
- Are pregnant or breastfeeding.
- Have indwelling catheters.
- Received prior decolonization treatment within last 6 months of enrollment.
- Have allergy to study medication.
- Are colonized with MRSA strain resistant to study medication.
- Have active infection requiring systemic antimicrobials.
- Are household contacts to index case.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Joseph Kimlead
- Alberta Health servicescollaborator
Study Sites (1)
Foothills Medical Center
Calgary, Alberta, T2N 2T9, Canada
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Thomas J Louie, MD
University of Calgary
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Clinical Assistant Professor
Study Record Dates
First Submitted
November 1, 2010
First Posted
November 2, 2010
Study Start
July 1, 2010
Primary Completion
April 1, 2012
Study Completion
November 1, 2012
Last Updated
February 15, 2013
Record last verified: 2013-02