Control of MRSA in Nursing Homes: Decolonization vs Standard Precautions

NCT01138462 | Completed

• 1 other identifier: Protocole 96/10
• Study Type: interventional
• Target: 157
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to determine the better approach between the currently procedure (i.e. standards precautions) and a reinforced strategy to control MRSA transmission in the institutionalized population of nursing homes in Canton of Vaud, Switzerland.

Conditions

Methicillin-Resistant Staphylococcus Aureus

Keywords

Methicillin-Resistant Staphylococcus aureus; Decolonisation; Nursing homes; Infection Control

Outcome Measures

Primary Outcomes (1)

• To determine the change in prevalence of MRSA carriage among residents of each Nursing homes group at the end of the one study year

  in each control and intervention nursing home: MRSA screening of all residents of nursing homes of Canton Vaud, at baseline and 1 year later, in order to compare MRSA prevalence changes at nursing homes levels

  1 year

Secondary Outcomes (1)

• To determine the effectiveness of the reinforced strategy to prevent MRSA infection, compared to the standard strategy

  1 year

Study Arms (2)

Standard Precautions

NO INTERVENTION

control arm, standards precautions for all residents living in the nursing home of control arm, including MRSA carriers

Intervention

OTHER

Intervention arm, standards precautions for all residents living in nursing homes of intervention arm, and topical decolonization for MRSA carriers, including environmental disinfection

Other: intervention

Interventions

intervention OTHER

5 days topical decolonisation including nasal mupirocin tid, chlorhexidine mouth wash tid, chlorhexidine body wash once daily. Daily direct resident's environmental disinfection during decolonisation.

Also known as: topical MRSA decolonisation and environmental disinfection

Intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• all nursing homes of canton Vaud, Switzerland, that give the consent of participation

You may not qualify if:

• \- refusal to participate
• \- all MRSA positive residents living in a Nursing Home included in the intervention group
• residents that refuse to be screened or refused the decolonisation
• life expectancy shorter of 7 days
• known intolerance of disinfectant/ topical antibiotics used in the protocol
• active MRSA infection
• asymptomatic MRSA bacteriuria
• stage IV wound (according to National Pressure Ulcer Advisory Panel)

Sponsors & Collaborators

• University of Lausanne Hospitals: lead

Related Publications (1)

• Bellini C, Petignat C, Masserey E, Bula C, Burnand B, Rousson V, Blanc DS, Zanetti G. Universal screening and decolonization for control of MRSA in nursing homes: a cluster randomized controlled study. Infect Control Hosp Epidemiol. 2015 Apr;36(4):401-8. doi: 10.1017/ice.2014.74.

  PMID: 25782894 BACKGROUND

MeSH Terms

Interventions

Methods

Intervention Hierarchy (Ancestors)

Investigative Techniques

Study Officials

• Giorgio Zanetti, MD

  University Hospital of Lausanne, Switzerland

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: June 4, 2010
• First Posted: June 7, 2010
• Study Start: June 1, 2010
• Primary Completion: December 1, 2011
• Study Completion: December 1, 2011
• Last Updated: March 30, 2020

Record last verified: 2020-03