Cytokines and Sevoflurane During Surgery
Effects of Inhalation Anaesthesia With Sevoflurane on Cytokine Response in Patients Submitted to Otorhinolaryngological Surgery
1 other identifier
observational
30
1 country
1
Brief Summary
The aim of the present study was to evaluate the effects of anaesthesia with sevoflurane and surgery on cytokines response.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Jul 2009
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2010
CompletedFirst Submitted
Initial submission to the registry
October 29, 2010
CompletedFirst Posted
Study publicly available on registry
November 1, 2010
CompletedNovember 1, 2010
October 1, 2010
5 months
October 29, 2010
October 29, 2010
Conditions
Keywords
Study Arms (2)
Volunteers
Healthy volunteers not submitted to anesthesia nor surgery.
Sevoflurane Group
This group was submitted to inhalational anesthesia with sevoflurane and otorhinolaryngological surgery.
Eligibility Criteria
Thirty adult patients ASA I physical status were allocated in 2 grups: 15 volunteers, not submitted to anesthesia and surgery, and 15 patients scheduled for tympanoplasty or septoplasty anesthetized with sevoflurane at 2,5%. Blood samples were drawn at 4 moments: before induction of anaesthesia, before surgery, at 120 minutes after anaesthesia induction, and on the postoperative first day. Blood samples from volunteers were drawn only once.
You may qualify if:
- both gender, ASA I physical status, 18-50 years old, tympanoplasty and septoplasty.
You may not qualify if:
- Malignant or genetical diseases; diabetes; smoking; elicit drugs, recent RX radiation.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Botucatu Medical School
Botucatu, São Paulo, 18618-970, Brazil
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jose EB Orosz, MD
Botucatu Medical School
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
October 29, 2010
First Posted
November 1, 2010
Study Start
July 1, 2009
Primary Completion
December 1, 2009
Study Completion
June 1, 2010
Last Updated
November 1, 2010
Record last verified: 2010-10