NCT01218945

Brief Summary

The repair of large osseous defects remains still unsolved. Aim of this study is to isolate and cultivate fat-derived progenitor cells and differentiation into osteoblasts. Therefore, our research idea is to pre-engineer large synthetic bone grafts and study the vascularization process in vivo.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
33

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Nov 2009

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2009

Completed
11 months until next milestone

First Submitted

Initial submission to the registry

September 29, 2010

Completed
12 days until next milestone

First Posted

Study publicly available on registry

October 11, 2010

Completed
2.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2012

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2012

Completed
Last Updated

June 19, 2013

Status Verified

June 1, 2013

Enrollment Period

3.1 years

First QC Date

September 29, 2010

Last Update Submit

June 18, 2013

Conditions

Overweight

Study Arms (1)

Fat Removal

Patients undergoing surgical fat removal

Procedure: Cell Culture

Interventions

Cell CulturePROCEDURE

Aim of this study is to isolate and cultivate fat-derived progenitor cells and differentiation into osteoblasts. Therefore, our research idea is to pre-engineer large synthetic bone grafts and study the vascularization process in vivo.

Fat Removal

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients admitted for reconstructive surgery

You may qualify if:

  • German-speaking patients aged 18-70 admitted to the Clinic of Reconstructive surgery for reconstructive surgery and fat-excision.

You may not qualify if:

  • Drug-abuse, neoplasia and metabolic disorders

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital Zurich, Clinic of Reconstructive Surgery

Zurich, Canton of Zurich, 8091, Switzerland

Location

Biospecimen

Retention: SAMPLES WITH DNA

Human adipose-derived stem cells from human fat

MeSH Terms

Conditions

Overweight

Interventions

Cell Culture Techniques

Condition Hierarchy (Ancestors)

OvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Cytological TechniquesClinical Laboratory TechniquesDiagnostic Techniques and ProceduresDiagnosisInvestigative TechniquesCulture TechniquesIn Vitro Techniques

Study Officials

  • Maurizio Calcagni, MD

    University Hospital Zurich, Clinic of Reconstructive Surgery

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 29, 2010

First Posted

October 11, 2010

Study Start

November 1, 2009

Primary Completion

December 1, 2012

Study Completion

December 1, 2012

Last Updated

June 19, 2013

Record last verified: 2013-06

Locations

CH(1)