Involvement of Translation Initiation Factors in the Immune Response in the Elderly

NCT01215604 | Unknown DMC

• 1 other identifier: MMC10156-2010CTIL
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators propose that the translation initiation factors eIF4E and eIF4GI may be involved in resolution of acute inflammation (regardless of age). Furthermore, the investigators suggest that differences in translation initiation factors state of activation may contribute to inflammation. Finally, the investigators hypothesize that differences in translation initiation factors state of activation may underlie the immune compromised state of the very elderly affording additional explanation for the heightened morbidity from infection in this group. In the current study the investigators aim to test these hypotheses by measuring the levels of eIF4E and eIF4G, their regulators, and targets in elderly (65-84yrs) and very elderly (85yrs\<) patients hospitalized at Meir hospital for acute infection and after their recovery (detailed in study design).

Conditions

Elderly Patient; Infection

Keywords

elderly patients; acute infection; translation initiation factors; eIF4E; eIF4G

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patient aged \>65 years admitted to internal medicine or geriatric departments due to acute infection with fever and leukocytosis.

You may qualify if:

• elderly patients (65\<)
• hospitalized for acute infection (fever 38c\<, leukocytosis)

You may not qualify if:

• patients with dementia who can not sign informed consent of institutional Helsinki committee
• patient with active cancer with active chemotherapy treatment

Sponsors & Collaborators

• Meir Medical Center: lead

Study Sites (1)

Meir Medical Center

Kfar Saba, Israel

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Blood samples of elderly patients diagnosed with acute infection will be collected at admittance to Meir hospital and on recovery (24-48 hours without fever and leukocytosis)

MeSH Terms

Conditions

Infections

Study Officials

• Rachel Heffez Ayzenfeld, MD

  Meir Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 5, 2010
• First Posted: October 6, 2010
• Study Start: October 1, 2010
• Primary Completion: October 1, 2011
• Study Completion: October 1, 2012
• Last Updated: March 19, 2012

Record last verified: 2012-03

Locations

IL (1)