Retinal Vascular Reactivity in Subjects With Newly Diagnosed Glaucoma Before and After Selective Laser Trabeculoplasty
1 other identifier
observational
12
1 country
1
Brief Summary
The purpose of this study is to assess retinal blood flow and vascular reactivity in patients with newly diagnosed primary open angle glaucoma pre- and post-primary Selective Laser Trabeculoplasty(SLT). Canon Laser Blood Flowmeter will be used for the assessment of retinal blood flow.
Trial Health
Trial Health Score
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participants targeted
Target at below P25 for all trials
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Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 2008
CompletedFirst Submitted
Initial submission to the registry
June 29, 2010
CompletedFirst Posted
Study publicly available on registry
September 28, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2011
CompletedSeptember 28, 2010
September 1, 2010
3 years
June 29, 2010
September 27, 2010
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
blood flow
The Canon Laser Blood Flowmetry will be used to assess the retinal blood flow.
before and two-week after SLT
Secondary Outcomes (1)
Intraocuclar pressure
before and two-week after SLT
Study Arms (1)
untreated glaucoma patients
We will evaluate the blood flow before and after Selective Laser Trabeculoplasty in patients with primary open angel glaucoma.
Interventions
Patient will have selective laser trabeculoplasty as the first treatment for glaucoma. This treatment will be dictated clinically, since we do not assign the interventions.
Eligibility Criteria
patient with untreated primary open angle glaucoma
You may qualify if:
- Age 40-75 years (Male or Female)
- Best corrected visual acuity of at least 20/40
- No previous treatment for glaucoma
- Ametropia less than ±6.0 DS and ±2.5 DC)
- Non-smoker
- No cardiovascular/respiratory disorders
You may not qualify if:
- Past history of diabetes and cerebrovascular accident
- Vascular occlusive disease affecting the ocular circulation such as: diabetic retinopathy, retinal vein occlusion and retinal artery occlusion
- Previous intraocular surgery
- Ocular media opacities limiting the use of the imaging tests
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Torontolead
- University of Western Ontario, Canadacollaborator
Study Sites (1)
Toronto Western Hospital
Toronto, Ontario, M5T2S8, Canada
Related Publications (1)
Venkataraman ST, Hudson C, Rachmiel R, Buys YM, Markowitz SN, Fisher JA, Trope GE, Flanagan JG. Retinal arteriolar vascular reactivity in untreated and progressive primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2010 Apr;51(4):2043-50. doi: 10.1167/iovs.09-3630. Epub 2009 Nov 11.
PMID: 19907031BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Chris Hudson, PhD
University of Toronto
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
June 29, 2010
First Posted
September 28, 2010
Study Start
November 1, 2008
Primary Completion
November 1, 2011
Last Updated
September 28, 2010
Record last verified: 2010-09