Effect of SLT Location on Treatment Outcomes

NCT03164941 | Unknown

• 1 other identifier: 0000000000
• Study Type: observational
• Target: 84
• Locations: 1 country
• Sites: 1

Brief Summary

Selective Laser Trabeculoplasty (SLT) is a glaucoma treatment that has been shown to effectively lower intraocular pressure by increasing aqueous outflow through macrophage recruitment. There is evidence of increased drainage in the nasal quadrants of the eye. This study aims to compare whether there is a difference in the reduction of eye pressure when SLT is performed nasally and temporally.

Conditions

Glaucoma

Keywords

selective laser trabeculoplasty; practice; treatment; intraocular pressure

Outcome Measures

Primary Outcomes (1)

• Intraocular Pressure

  The primary outcome in this study is the change in intraocular pressure from baseline to the 1 year follow-up visit (continuous variable). The percentage decrease in IOP from baseline will also be calculated and compared between the two groups.

  1 year

Study Arms (2)

Nasal SLT

This cohort will have 180 degree SLT completed on the nasal quadrants of the trabecular meshwork.

Procedure: Selective Laser Trabeculoplasty

Temporal SLT

This cohort will have 180 degree SLT completed on the temporal quadrants of the trabecular meshwork.

Procedure: Selective Laser Trabeculoplasty

Interventions

Selective Laser Trabeculoplasty PROCEDURE

Laser treatment for glaucoma.

Nasal SLT; Temporal SLT

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The patients will be recruited from the glaucoma practice at St. Joseph's Healthcare Hamilton. A baseline clinical eye examination will be completed to include or exclude the participant from the study according to the criteria below. The baseline exam will include a comprehensive questionnaire of the participant's past ocular history, relevant systemic diseases, glaucoma risk factors, and surgical history.

You may qualify if:

• Diagnosis of open angle glaucoma, ocular hypertension, pigmentary dispersion syndrome and pseudoexfoliation syndrome
• Participant must be over 18 years of age
• IOP \> 16mmHg on at least two consecutive occasions separated by one month
• Two sighted eyes with visual acuity of 20/200 or better
• Informed consent from patient

You may not qualify if:

• Diagnosis of secondary OAG (aside from pigmentary and pseudoexfoliation glaucoma) or narrow angle glaucoma
• Previous incisional glaucoma surgery
• Incisional glaucoma surgery scheduled within 1 year of intervention
• Corneal disease affecting visualization of anterior chamber of the eye
• Treatment or plan to treat with topical or systemic steroids
• Previous selective laser trabeculoplasty treatment

Sponsors & Collaborators

• St. Joseph's Healthcare Hamilton: lead

Study Sites (1)

St Joseph's Healthcare Hamilton - King Campus

Hamilton, Ontario, Canada

RECRUITING

MeSH Terms

Conditions

Glaucoma

Condition Hierarchy (Ancestors)

Ocular Hypertension; Eye Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Ophthalmologist

Study Record Dates

• First Submitted: May 22, 2017
• First Posted: May 24, 2017
• Study Start: July 1, 2017
• Primary Completion: December 1, 2019
• Study Completion: December 1, 2020
• Last Updated: May 24, 2017

Record last verified: 2017-05

Locations

CA (1)