The DC Cohort Longitudinal HIV Status Neutral Study
DC Cohort
Development of a City-Wide Cohort of HIV-Infected Persons in Care in the District of Columbia: The DC Cohort
2 other identifiers
observational
19,000
1 country
14
Brief Summary
The goal of the DC Cohort is to establish a clinic-based city-wide longitudinal cohort that will describe clinical outcomes, and improve the quality of care for patients diagnosed with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) or at higher risk for acquiring HIV and receiving care in Washington, DC.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2011
Longer than P75 for all trials
14 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 21, 2010
CompletedFirst Posted
Study publicly available on registry
September 22, 2010
CompletedStudy Start
First participant enrolled
January 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2041
ExpectedStudy Completion
Last participant's last visit for all outcomes
January 1, 2041
February 2, 2026
January 1, 2026
30 years
September 21, 2010
January 29, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
viral suppression among persons with HIV
The study will assess rates of viral suppression (defined as an HIV RNA test less than 200 copies/ml) from enrollment to 10 years post enrollment.
through study completion, an average of 10 years from enrollment to the end of study follow up
clinical outcomes persons at higher risk for acquiring HIV
Persons who are receiving HIV preventive services will be followed longitudinally to assess time to HIV positivity from baseline to 5 years post enrollment
through study completion, an average of 5 years from enrollment to the end of study follow up period
Study Arms (2)
Treatment Cohort
These are individuals who are diagnosed with HIV and receiving care at a participating DC Cohort clinical site.
Prevention Cohort
These are individuals who are receiving HIV preventive services at a participating DC Cohort site.
Eligibility Criteria
Study participants will include men, women and children receiving HIV prevention, care or treatment services at major publicly-funded, government and academic medical centers in the District of Columbia.
You may qualify if:
- Patient is receiving care for HIV at one or more of the twelve participating clinics in the DC Cohort.
- Patient is either age 18 years or older, or seeks HIV care independently and is able to understand and sign informed consent.
- Patient is a minor who is consented by a parent or legal guardian.
You may not qualify if:
- Patient is unable or refuses to provide informed consent.
- Minor children ages 12 through 17 who are unaware of their HIV status
- Persons receiving any antiretroviral prescription without evidence of HIV or Hepatitis B infection
- PrEP (e.g., TDF/FTC, Descovy, Apretude)
- Combination ART indicative of nPEP in an HIV-uninfected person
- Persons receiving an antiretroviral prescription indicative of DoxyPEP Doxycycline 200mg PO taken within 72 hrs of unprotected sexual encounter (or variations thereof where clearly not prescribed as a treatment course)
- Test positive for ≥1 bacterial STI (positive gonorrhea (GC/NG) or chlamydia (CT) test or positive syphilis test requiring treatment within one year)
- bacterial STI (GC, chlamydia, syphilis) tests at 2 or more different encounters
- HIV tests at 2 or more different encounters
- Patient requesting PrEP at their clinical visit
- Patient requesting nPEP at their clinical visit
- People who identify as injecting drugs
- Patients with a Z29.81 Encounter for HIV pre-exposure prophylaxis
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (14)
Kaiser Permanente Mid-Atlantic States
Washington D.C., District of Columbia, 20002, United States
Unity Health Care
Washington D.C., District of Columbia, 20003, United States
Georgetown University
Washington D.C., District of Columbia, 20007, United States
La Clinica Del Pueblo
Washington D.C., District of Columbia, 20009, United States
Whitman-Walker Health
Washington D.C., District of Columbia, 20009, United States
Children's National Medical Center--Pediatric Clinic
Washington D.C., District of Columbia, 20010, United States
Washington Hospital Center
Washington D.C., District of Columbia, 20010, United States
Washington Health Institute
Washington D.C., District of Columbia, 20017, United States
Family and Medical Counseling Service
Washington D.C., District of Columbia, 20020, United States
George Washington Medical Faculty Associates
Washington D.C., District of Columbia, 20037, United States
Howard University Hospital--Adult Clinic
Washington D.C., District of Columbia, 20060, United States
Howard University Hospital--Pediatric Clinic
Washington D.C., District of Columbia, 20060, United States
Veterans Affairs Medical Center
Washington D.C., District of Columbia, 20422, United States
Us Helping Us, People into Living, Inc.
Washington D.C., District of Columbia, United States
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Amanda D Castel, MD, MPH
George Washington University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- PI
Study Record Dates
First Submitted
September 21, 2010
First Posted
September 22, 2010
Study Start
January 1, 2011
Primary Completion (Estimated)
January 1, 2041
Study Completion (Estimated)
January 1, 2041
Last Updated
February 2, 2026
Record last verified: 2026-01