Repetitive Transcranial Magnetic Stimulation(rTMS) in the Treatment of Depression
1 other identifier
observational
40
1 country
1
Brief Summary
The objective of this study is to investigate the antidepressant efficacy of rTMS, and to assess cortical metabolism before and after rTMS sessions in patients with major depression. We also aimed to investigate differences between the responders and nonresponders to rTMS and what would predict clinical response to rTMS.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Feb 2006
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2006
CompletedFirst Submitted
Initial submission to the registry
September 8, 2010
CompletedFirst Posted
Study publicly available on registry
September 10, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2016
CompletedDecember 31, 2015
December 1, 2015
10.8 years
September 8, 2010
December 30, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Hamilton depression rating scale (HAM-D 17)
measuring instrument of severity of depressive symptoms
baseline, 1, 2, and 4 weeks after TMS
Study Arms (1)
repetitive Transcranial Magnetic Stimulation
repetitive Transcranial Magnetic Stimulation is a depressive patient group treated with rTMS
Interventions
10 times repetitive TMS, high frequency
Eligibility Criteria
Patients with major depressive disorder, who were not responsive to antidepressants
You may qualify if:
- Twenty patients fulfilling the diagnostic criteria of major depression according to DSM IV will be enrolled in the study.
- Antidepressant medication will be maintained throughout the study period.
You may not qualify if:
- To exclude the effect of drug changes on post-rTMS cerebral glucose metabolism, the combinations and dosage of pre-rTMS antidepressant drugs will remain unchanged until the post-rTMS 18FDG PET is done.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Samsung Medical Center
Seoul, Kangnam-Ku, 135-710, South Korea
Biospecimen
serum, plasma and DNAs
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Doh K KIm, Ph.D
Samsung Medical Center
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- M.D., Ph.D. / Professor
Study Record Dates
First Submitted
September 8, 2010
First Posted
September 10, 2010
Study Start
February 1, 2006
Primary Completion
December 1, 2016
Study Completion
December 1, 2016
Last Updated
December 31, 2015
Record last verified: 2015-12