Reference Values of Cerebrospinal Fluid Outflow Resistance and Intracranial Pressure in Healthy Elderly

NCT01188382 | Completed

• 1 other identifier: Hydrocephalus100
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Objective. The intracranial pressure and cerebrospinal outflow resistance are essential parameters to describe the cerebrospinal fluid dynamic system. Outflow resistance effects intracranial pressure, pulse amplitudes, cerebrospinal fluid absorption as well as the compliance of the system. The objective of this study was to determine the reference values in the elderly. Methods. Elderly people (60-82 years), considering themselves healthy, were recruited through an ad in the local paper. All were evaluated with a 3 Tesla magnetic resonance imaging apparatus. Subjects were eligible if they did not have any psychiatric or neurological disorder or signs of advanced atherosclerotic disease. Intracranial pressure and outflow resistance were determined by a constant pressure infusion method with the patient in the supine position. The study population consisted of 40 subjects (mean age 70 years; 23 women).

Conditions

Healthy Elderly

Keywords

Intracranial pressure; resistance; CSF outflow; elderly; reference value

Outcome Measures

Primary Outcomes (1)

• CSF outflow resistance

Secondary Outcomes (1)

• Intracranial pressure

Study Arms (1)

Healthy elderly

Healthy elderly 60-82 years; Normal MRI; No psychiatric or neurological disorder and without signs of advanced atherosclerotic disease

Procedure: CSF dynamic investigation

Interventions

CSF dynamic investigation PROCEDURE

Healthy elderly

Eligibility Criteria

• Age: 60 Years - 82 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Healthy elderly

You may qualify if:

• Healthy
• years

You may not qualify if:

• Psychiatric or neurological disorder or advanced atherosclerotic disease

Sponsors & Collaborators

• Umeå University: lead

Study Sites (1)

Dep Clincial Neuroscience, Umeå university

Umeå, 901 85, Sweden

Location

Related Publications (1)

• Jacobsson J, Qvarlander S, Eklund A, Malm J. Comparison of the CSF dynamics between patients with idiopathic normal pressure hydrocephalus and healthy volunteers. J Neurosurg. 2018 Nov 16;131(4):1018-1023. doi: 10.3171/2018.5.JNS173170. Print 2019 Oct 1.

  PMID: 30497143 DERIVED

Related Links

• Web site of the Umeå hydrocephalus research group

Study Officials

• Jan I Malm, PhD, MD

  Umeå University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: August 17, 2010
• First Posted: August 25, 2010
• Study Start: August 1, 2007
• Primary Completion: December 1, 2008
• Study Completion: December 1, 2008
• Last Updated: August 25, 2010

Record last verified: 2010-06

Locations

SE (1)