NCT01188213

Brief Summary

The aim of this study was to determine the efficacy of methylsulfonylmethane (MSM) in treating patients with knee OA.

Trial Health

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 21, 2010

Completed
4 days until next milestone

First Posted

Study publicly available on registry

August 25, 2010

Completed
Last Updated

August 25, 2010

Status Verified

May 1, 2005

First QC Date

August 21, 2010

Last Update Submit

August 24, 2010

Conditions

Knee Osteoarthritis

Outcome Measures

Primary Outcomes (1)

  • WOMAC questionnaire

Study Arms (1)

Purified MSM

EXPERIMENTAL
Dietary Supplement: Methylsulfonylmethane (MSM)

Interventions

Methylsulfonylmethane (MSM)DIETARY_SUPPLEMENT
Purified MSM

Eligibility Criteria

Age40 Years - 70 Years
Sexall
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • symptomatic knee OA for at least 6 months according to the clinical criteria of the American College of Rheumatology (ACR)
  • radiographic confirmed knee OA according to the Kellgren \& Lawrence scale

You may not qualify if:

  • acute septic arthritis
  • inflammatory arthritis
  • any other type of arthritis
  • history of knee buckling or recent knee injury
  • lack of physical or mental bility to perform or comply with the treatment procedure
  • diabetes mellitus
  • fibromyalgia or other chronic pain syndromes
  • concurrent anti-coagulant/anti-platelet drugs
  • arthroscopy or intra-articular injections in the previous 3 months

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • Debbi EM, Agar G, Fichman G, Ziv YB, Kardosh R, Halperin N, Elbaz A, Beer Y, Debi R. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011 Jun 27;11:50. doi: 10.1186/1472-6882-11-50.

    PMID: 21708034DERIVED

MeSH Terms

Conditions

Osteoarthritis, Knee

Interventions

dimethyl sulfone

Condition Hierarchy (Ancestors)

OsteoarthritisArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Study Design

Study Type
interventional
Phase
not applicable
Sponsor Type
OTHER GOV

Study Record Dates

First Submitted

August 21, 2010

First Posted

August 25, 2010

Last Updated

August 25, 2010

Record last verified: 2005-05