Sex Differences in Attentional Bias in Marijuana-dependent Individuals
1 other identifier
interventional
40
1 country
1
Brief Summary
The purpose of this study is to explore sex differences in cognitive functioning and responses to marijuana-related items, and to determine whether stress impacts these measures. Hypothesis 1: Attentional bias will be greater for marijuana cues in male marijuana-dependent subjects relative to female marijuana-dependent or non-dependent male controls. Hypothesis 2: Marijuana-dependent females will exhibit greater stress-induced changes in attentional bias and cognitive functioning than marijuana-dependent males.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Aug 2009
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2009
CompletedFirst Submitted
Initial submission to the registry
November 17, 2009
CompletedFirst Posted
Study publicly available on registry
August 11, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2011
CompletedApril 14, 2011
April 1, 2011
1.5 years
November 17, 2009
April 13, 2011
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Primary outcome measures will be obtained from the auditory odd-ball task: differences while viewing the marijuana vs neutral video in reaction time (msec), errors of omission (%), and errors of commission (%).
~ 3 hours
Secondary Outcomes (1)
Secondary measures include subjective (craving and stress), physiological (heart rate and skin conductance), and stress hormone level (cortisol) assessments.
~ 3 hours
Study Arms (2)
non-marijuana dependent controls
ACTIVE COMPARATORMarijuana-dependent subjects
EXPERIMENTALInterventions
The Paced Auditory Serial Addition Task (PASAT-C), has been modified for use as a computerized laboratory-based stressor. Single digits are presented, and the patient must add each new digit to the one immediately prior to it and click on the appropriate answer. Failure to do so in the allotted time results in a noxious error sound.
Eligibility Criteria
You may not qualify if:
- Current depression
- Bipolar disorder
- Attention deficit hyperactivity disorder
- History of psychosis
- Suicidal or homicidal intent
- Significant cognitive deficits
- Dependence on any substance other than marijuana, nicotine, or caffeine.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Medical University of South Carolina, Dept. of Psychiatry/Clinical Neuroscience Division
Charleston, South Carolina, 29425, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Kimber L Price, PhD
Medical University of South Carolina
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
November 17, 2009
First Posted
August 11, 2010
Study Start
August 1, 2009
Primary Completion
February 1, 2011
Study Completion
February 1, 2011
Last Updated
April 14, 2011
Record last verified: 2011-04