Acute Effects of Coffee on Appetite and Inflammation Markers, Glucose Metabolism and Energy Intake

NCT01174576 | Completed Results

• 1 other identifier: CofSt
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the study is to investigate whether caffeinated and decaffeinated coffee consumption has acute effects on subjective appetite feelings, energy intake and biochemical markers related to appetite, inflammation and glucose metabolism compared to water consumption.

Conditions

Health

Keywords

coffee; appetite; energy intake; inflammation; cortisol; glucose; randomized controlled trial

Outcome Measures

Primary Outcomes (11)

• Ghrelin Total Area Under the Curve

  Total area under the curve was defined as the sum of the areas under and over the baseline using the trapezoidal rule. The time points for the calculations were 15 min before beverage consumption, immediately after beverage consumption, 15, 30, 60, 90, 120, 150, 180 min postconsumption.

  15 min before ingestion to 3 hr post ingestion

• Peptide Tyrosine Tyrosine (PYY) Total Area Under the Curve

  Total area under the curve was defined as the sum of the areas under and over the baseline using the trapezoidal rule. The time points for the calculations were 15 min before beverage consumption, immediately after beverage consumption, 15, 30, 60, 90, 120, 150, 180 min postconsumption.

  15 min before ingestion to 3 hr post ingestion

• Glucagon-like Peptide-1 (GLP-1) Total Area Under the Curve

  Total area under the curve was defined as the sum of the areas under and over the baseline using the trapezoidal rule. The time points for the calculations were 15 min before beverage consumption, immediately after beverage consumption, 15, 30, 60, 90, 120, 150, 180 min postconsumption.

  15 min before ingestion to 3 hr post ingestion

• Adiponectin Total Area Under the Curve

  Total area under the curve was defined as the sum of the areas under and over the baseline using the trapezoidal rule. The time points for the calculations were 15 min before beverage consumption, immediately after beverage consumption, 15, 30, 60, 90, 120, 150, 180 min postconsumption.

  15 min before ingestion to 3 h post ingestion

• Inteleukin-6 Total Area Under the Curve

  Total area under the curve was defined as the sum of the areas under and over the baseline using the trapezoidal rule. The time points for the calculations were 15 min before beverage consumption, immediately after beverage consumption, 15, 30, 60, 90, 120, 150, 180 min postconsumption.

  15 min before ingestion to 3 hr post ingestion

• Interleukin-18 Total Area Under the Curve

  Total area under the curve was defined as the sum of the areas under and over the baseline using the trapezoidal rule. The time points for the calculations were 15 min before beverage consumption, immediately after beverage consumption, 15, 30, 60, 90, 120, 150, 180 min postconsumption.

  15 min before ingestion to 3 hr post ingestion

• Glucose Total Area Under the Curve

  Total area under the curve was defined as the sum of the areas under and over the baseline using the trapezoidal rule. The time points for the calculations were 15 min before beverage consumption, immediately after beverage consumption, 15, 30, 60, 90, 120, 150, 180 min postconsumption.

  15 min before ingestion to 3 hr post ingestion

• Insulin Total Area Under the Curve

  Total area under the curve was defined as the sum of the areas under and over the baseline using the trapezoidal rule. The time points for the calculations were 15 min before beverage consumption, immediately after beverage consumption, 15, 30, 60, 90, 120, 150, 180 min postconsumption.

  15 min before ingestion to 3 hr post ingestion

• Cortisol Total Area Under the Curve

  Total area under the curve was defined as the sum of the areas under and over the baseline using the trapezoidal rule. The time points for the calculations were 15 min before beverage consumption, immediately after beverage consumption, 15, 30, 60, 90, 120, 150, 180 min postconsumption.

  15 min before ingestion to 3 hr post ingestion

• Energy ad Libitum Meal

  The energy of first meal 3 hr after ingestion

  3 hr post ingestion

• Total Energy Intake

  the energy consumed at breakfast, ad libitum meal and rest of the experimental day

  1 d

Secondary Outcomes (1)

• Serum Antioxidant Capacity Total Area Under the Curve

  15 min before ingestion to 21/2 hr post ingestion

Study Arms (3)

caffeinated coffee

EXPERIMENTAL

200 mL caffeinated coffee with 3 mg caffeine per kg body weight

Other: caffeinated and decaffeinated coffee

decaffeinated coffee

EXPERIMENTAL

200 mL decaffeinated coffee, same amount as caffeinated coffee

Other: caffeinated and decaffeinated coffee

Water

EXPERIMENTAL

200 mL, control intervention

Other: caffeinated and decaffeinated coffee

Interventions

caffeinated and decaffeinated coffee OTHER

3 treatments on separate days, i.e. a standard breakfast with oral ingestion of 200 ml of either caffeinated coffee (3mg caffeine/kg body weight), decaffeinated coffee or water

Water; caffeinated coffee; decaffeinated coffee

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• healthy
• non-obese

You may not qualify if:

• smokers
• restrained eaters (as this was evaluated using the Dutch Eating Behaviour Questionnaire and a total score \> 2.5)
• those who reported slimming or any other dietary regime
• abstainers from caffeine sources
• athletes during competition period
• participants with a known diagnosis of either hypertension, diabetes, impaired glucose tolerance or a fasting blood glucose concentration above 125 mg/dl
• subjects on medication for hypertension or on medication known to alter glucose metabolism
• subjects who were on medication that may have an impact on appetite and sensory functioning or who reported a metabolic or endocrine disease, gastrointestinal disorders, or a history of medical or surgical events that may have affected the study outcomes

Sponsors & Collaborators

• Harokopio University: lead
• Beth Israel Deaconess Medical Center: collaborator

Study Sites (1)

Metabolic Unit of the Department of Nutrition and Dietetics, Harokopio University

Athens, 17671, Greece

Location

Related Publications (1)

• Gavrieli A, Yannakoulia M, Fragopoulou E, Margaritopoulos D, Chamberland JP, Kaisari P, Kavouras SA, Mantzoros CS. Caffeinated coffee does not acutely affect energy intake, appetite, or inflammation but prevents serum cortisol concentrations from falling in healthy men. J Nutr. 2011 Apr 1;141(4):703-7. doi: 10.3945/jn.110.137323. Epub 2011 Feb 23.

  PMID: 21346100 DERIVED

MeSH Terms

Conditions

Inflammation

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Limitations and Caveats

the results cannot be generalized to other population groups, as participants were selected according to specific criteria.

Results Point of Contact

• Title: Dr. Mary Yannakoulia
• Organization: Harokopio University

myianna@hua.gr

00302109549175

Study Officials

• Mary Yannakoulia, PhD

  Harokopio University

  STUDY DIRECTOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: July 26, 2010
• First Posted: August 3, 2010
• Study Start: February 1, 2009
• Primary Completion: May 1, 2009
• Study Completion: May 1, 2009
• Last Updated: September 30, 2013
• Results First Posted: September 30, 2013

Record last verified: 2013-07

Locations

GR (1)