A Study on the Prevalence of Obstructive Sleep Apnea in Patients With Type II Diabetes Mellitus

NCT01172093 | Completed DMC

• 1 other identifier: UW07-060
• Study Type: observational
• Target: 177
• Locations: 1 country
• Sites: 1

Brief Summary

OSA is prevalent among patients with type II DM

Conditions

Obstructive Sleep Apnea; Diabetes Mellitus

Keywords

obstructive sleep apnea; prevalence; diabetes mellitus; Chinese

Outcome Measures

Primary Outcomes (1)

• presence of OSA

  The diagnosis of OSA will be confirmed with polysomnography

  measured at a single time point during the recruitment period(2007-08), by polysomnography

Secondary Outcomes (2)

• severity of OSA

  measured at a single time point during the recruitment period(2007-08), by polysomnography

• glycemic control

  measured at a single time point, when the subjects were admitted for polysomnography (during 2007-08)

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All Chinese subjects with type 2 diabetes mellitus being followed up at the diabetic clinic of a University affiliated hospital

You may qualify if:

• Patients, age 18 - 75, with type 2 diabetes mellitus, including those on diet, on oral-hypoglycaemic agents or on insulin
• Patients who are able to give written consent to undergo polysomnography

You may not qualify if:

• Patients who are unable or unwilling to give written consent to participate in the study
• Patients with unstable medical illness or poor functional performance
• Patients with recent myocardial infarction or hospital admission for congestive heart failure or cardiac arrhythmia in the past three months
• Patients on renal replacement therapy for diabetic nephropathy or chronic renal failure, or plan to start renal replacement therapy in the coming six months
• Patients suffered from recent stroke in the past six months or previous history of stroke with significant focal neurological deficit
• Patients with type I diabetes
• Pregnant lady or lactating women

Sponsors & Collaborators

• The University of Hong Kong: lead

Study Sites (1)

Queen Mary Hospital

Hong Kong, 852, Hong Kong

Location

Related Publications (7)

• Aronsohn RS, Whitmore H, Van Cauter E, Tasali E. Impact of untreated obstructive sleep apnea on glucose control in type 2 diabetes. Am J Respir Crit Care Med. 2010 Mar 1;181(5):507-13. doi: 10.1164/rccm.200909-1423OC. Epub 2009 Dec 17.

  PMID: 20019340 BACKGROUND

• Elmasry A, Lindberg E, Berne C, Janson C, Gislason T, Awad Tageldin M, Boman G. Sleep-disordered breathing and glucose metabolism in hypertensive men: a population-based study. J Intern Med. 2001 Feb;249(2):153-61. doi: 10.1046/j.1365-2796.2001.00787.x.

  PMID: 11240844 BACKGROUND

• Resnick HE, Redline S, Shahar E, Gilpin A, Newman A, Walter R, Ewy GA, Howard BV, Punjabi NM; Sleep Heart Health Study. Diabetes and sleep disturbances: findings from the Sleep Heart Health Study. Diabetes Care. 2003 Mar;26(3):702-9. doi: 10.2337/diacare.26.3.702.

  PMID: 12610025 BACKGROUND

• West SD, Nicoll DJ, Stradling JR. Prevalence of obstructive sleep apnoea in men with type 2 diabetes. Thorax. 2006 Nov;61(11):945-50. doi: 10.1136/thx.2005.057745. Epub 2006 Aug 23.

  PMID: 16928713 BACKGROUND

• Ronksley PE, Hemmelgarn BR, Heitman SJ, Hanly PJ, Faris PD, Quan H, Tsai WH. Obstructive sleep apnoea is associated with diabetes in sleepy subjects. Thorax. 2009 Oct;64(10):834-9. doi: 10.1136/thx.2009.115105. Epub 2009 Aug 12.

  PMID: 19679579 BACKGROUND

• Foster GD, Sanders MH, Millman R, Zammit G, Borradaile KE, Newman AB, Wadden TA, Kelley D, Wing RR, Sunyer FX, Darcey V, Kuna ST; Sleep AHEAD Research Group. Obstructive sleep apnea among obese patients with type 2 diabetes. Diabetes Care. 2009 Jun;32(6):1017-9. doi: 10.2337/dc08-1776. Epub 2009 Mar 11.

  PMID: 19279303 BACKGROUND

• Lam DC, Lui MM, Lam JC, Ong LH, Lam KS, Ip MS. Prevalence and recognition of obstructive sleep apnea in Chinese patients with type 2 diabetes mellitus. Chest. 2010 Nov;138(5):1101-7. doi: 10.1378/chest.10-0596. Epub 2010 Aug 12.

  PMID: 20705796 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

Plasma and serum samples were collected from subjects for batch assays for further research purposes

MeSH Terms

Conditions

Sleep Apnea, Obstructive; Diabetes Mellitus

Condition Hierarchy (Ancestors)

Sleep Apnea Syndromes; Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Officials

• David CL Lam, PhD

  The University of Hong Kong

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: July 27, 2010
• First Posted: July 29, 2010
• Study Start: January 1, 2007
• Primary Completion: June 1, 2008
• Study Completion: December 1, 2008
• Last Updated: July 29, 2010

Record last verified: 2010-07

Locations

HK (1)