Effects of Obstructive Sleep Apnea and/or Cigarette Smoking on Endothelial Function

NCT00957463 | Completed

• 1 other identifier: UW 08-023
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

The hypothesis of this study is that either obstructive sleep apnea (OSA) or cigarette smoking (CS) exposure would produce oxidative stress and inflammation leading to endothelial injury, and the combined exposure would be additive or synergistic.

Conditions

Obstructive Sleep Apnea; Smoking

Keywords

endothelial function

Outcome Measures

Primary Outcomes (1)

• reactive hyperemia induced peripheral arterial tone (RH-RAT) index

  baseline

Secondary Outcomes (1)

• circulatory metabolic and vascular inflammatory biomarkers

  baseline

Study Arms (4)

smoker, with high apnea-hypopnea index

subjects who smoke either in the past or currently, with confirmed moderate-severe OSA

smoker, mild OSA or without OSA

subjects who smoke either in the past or currently, with mild OSA or without OSA

nonsmoker, with high apnea-hypopnea index

subjects who never smoke, with confirmed moderate-severe OSA

nonsmoker, with mild OSA or without OSA

subjects who never smoke, with mild OSA or without OSA

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Consecutive subjects who undergo polysomnograms (PSG) in the Sleep Disorder Centre, Department of Medicine, Queen Mary Hospital, and who fulfill the study criteria will be recruited.

You may qualify if:

• No acute illness
• No hospitalization in past 4 weeks
• Absence of medical comorbidity such as hypertension, ischemic heart disease, diabetes and hyperlipidemia, renal impairment, vasculitis or Raynaud's syndrome, peripheral vascular disease especially Buerger's disease, aortic disease (aortic aneurysm or dilatation), cancer, thrombocytopenia, coagulation disorder or other chronic medical illness

You may not qualify if:

• Mentally incapacitated

Sponsors & Collaborators

• The University of Hong Kong: lead

Study Sites (1)

Queen Mary Hospital

Hong Kong, 852, Hong Kong

Location

Related Publications (6)

• Barnoya J, Glantz SA. Cardiovascular effects of secondhand smoke: nearly as large as smoking. Circulation. 2005 May 24;111(20):2684-98. doi: 10.1161/CIRCULATIONAHA.104.492215.

  PMID: 15911719 BACKGROUND

• Kashyap R, Hock LM, Bowman TJ. Higher prevalence of smoking in patients diagnosed as having obstructive sleep apnea. Sleep Breath. 2001 Dec;5(4):167-72. doi: 10.1007/s11325-001-0167-5.

  PMID: 11868156 BACKGROUND

• Lavie L, Lavie P. Smoking interacts with sleep apnea to increase cardiovascular risk. Sleep Med. 2008 Mar;9(3):247-53. doi: 10.1016/j.sleep.2007.03.018. Epub 2007 May 21.

  PMID: 17513169 BACKGROUND

• El Solh AA, Akinnusi ME, Baddoura FH, Mankowski CR. Endothelial cell apoptosis in obstructive sleep apnea: a link to endothelial dysfunction. Am J Respir Crit Care Med. 2007 Jun 1;175(11):1186-91. doi: 10.1164/rccm.200611-1598OC. Epub 2007 Feb 1.

  PMID: 17272785 BACKGROUND

• Bernhard D, Wang XL. Smoking, oxidative stress and cardiovascular diseases--do anti-oxidative therapies fail? Curr Med Chem. 2007;14(16):1703-12. doi: 10.2174/092986707781058959.

  PMID: 17627508 BACKGROUND

• Itzhaki S, Lavie L, Pillar G, Tal G, Lavie P. Endothelial dysfunction in obstructive sleep apnea measured by peripheral arterial tone response in the finger to reactive hyperemia. Sleep. 2005 May;28(5):594-600. doi: 10.1093/sleep/28.5.594.

  PMID: 16171272 BACKGROUND

MeSH Terms

Conditions

Sleep Apnea, Obstructive; Smoking

Condition Hierarchy (Ancestors)

Sleep Apnea Syndromes; Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Behavior

Study Officials

• Mary SM Ip, MD

  The University of Hong Kong

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: August 10, 2009
• First Posted: August 12, 2009
• Study Start: June 1, 2008
• Primary Completion: December 1, 2011
• Last Updated: December 30, 2014

Record last verified: 2014-12

Locations

HK (1)