NCT01166854

Brief Summary

The researcher wants to explore the genetic causes of muscle disease. The researcher is particularly interested in muscle disorders that occur in combination with diseases of bone that appear to be passed on from generation to generation. Diffuse Optical Spectroscopy will measure the concentrations of blood, water, and lipids (fats, for example) in your tissues. This device essentially measures the color of tissues in order to determine tissue physiology (its physical and chemical processes).

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
25

participants targeted

Target at below P25 for all trials

Timeline
50mo left

Started Jun 2010

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress80%
Jun 2010Jun 2030

Study Start

First participant enrolled

June 18, 2010

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

July 20, 2010

Completed
1 day until next milestone

First Posted

Study publicly available on registry

July 21, 2010

Completed
19.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2030

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2030

Last Updated

June 18, 2025

Status Verified

June 1, 2025

Enrollment Period

20 years

First QC Date

July 20, 2010

Last Update Submit

June 13, 2025

Conditions

Muscle DisorderBone Disorder

Keywords

muscle and bone disease

Outcome Measures

Primary Outcomes (1)

  • muscle disease

    1 week

Study Arms (1)

Muscle weakness

Diffuse Optical Spectroscopy

Device: Diffuse Optical Spectroscopy

Interventions

Diffuse Optical SpectroscopyDEVICE

Diffuse Optical Spectroscopy

Muscle weakness

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Study Population will be selected from Dr. Kimonis outpatient clinic at University of California Irvine.

You may qualify if:

  • diagnose of Muscle or bone disorders
  • with a combination of medical problems including muscle and bone disease and their family members.

You may not qualify if:

  • under 18 year of age
  • unrelated diagnosis

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hewitt Hall

Irvine, California, 92697, United States

RECRUITING

MeSH Terms

Conditions

Muscular DiseasesBone Diseases

Condition Hierarchy (Ancestors)

Musculoskeletal DiseasesNeuromuscular DiseasesNervous System Diseases

Study Officials

  • Virginia Kimonis, MD

    Beckman Laser Institute University of California Irvine

    PRINCIPAL INVESTIGATOR

  • Bruce Tromberg, PhD

    Beckman Laser Institute University of California Irvine

    STUDY DIRECTOR

Central Study Contacts

Marie Wencel, BS

CONTACT

949-824-0521mwencel@uci.edu

Virginia Kimonis, MD

CONTACT

714-456-5791vkimonis@hs.uci.edu

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Virginia Kimonis, MD, MRCP

Study Record Dates

First Submitted

July 20, 2010

First Posted

July 21, 2010

Study Start

June 18, 2010

Primary Completion (Estimated)

June 1, 2030

Study Completion (Estimated)

June 1, 2030

Last Updated

June 18, 2025

Record last verified: 2025-06

Locations

US(1)