Effect of Cervical Discharge Removal During ET on Pregnancy Rate
1 other identifier
interventional
492
1 country
1
Brief Summary
Pregnancy rate may be affected by multiple factors such as embryo transfer techniques. Even small differences in embryo transfer methods may affect pregnancy rates. There is an inconsistency about the effect of the removal of cervical discharge on embryo transfer outcomes. Some studies showed that cervical mucus removal before embryo transfer can increase pregnancy rate, however the others could not find any significant effect about the removal of cervical mucus on pregnancy or live birth rates. Given to the conflicting evidences, our study aimed to determine whether the cervical discharge removal has positive effect on pregnancy rate.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_2
Started May 2009
Shorter than P25 for phase_2
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2010
CompletedFirst Submitted
Initial submission to the registry
July 1, 2010
CompletedFirst Posted
Study publicly available on registry
July 2, 2010
CompletedSeptember 21, 2011
July 1, 2010
1 year
July 1, 2010
September 20, 2011
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Pregnancy rate
9 months after recruiting
Secondary Outcomes (4)
Fertilization rate
2 weeks
Implantation rate
1 month
Miscarriage rate
9 months
Live birth rate
9 months
Study Arms (2)
Cervical discharge removal
EXPERIMENTALCervical discharge will be removed using a cotton swab before embryo transfer during ICSI cycles
Control
ACTIVE COMPARATOREmbryo transfer without any intervention
Interventions
Cervical discharge will be removed using a cotton swab before embryo transfer during ICSI cycles
Eligibility Criteria
You may qualify if:
- Women who were candidate for fresh embryo transfer during IVF/ICSI cycles were eligible for this study if they had two or more good quality embryos and age fewer than 40
You may not qualify if:
- The patients with frozen-thawed embryo transfer cycle
- Those with oocyte donation cycle
- The women with uterine abnormality
- The women with submucosal and intramural myoma
- Who does not have good-quality embryos appropriate
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Royan Institutelead
Study Sites (1)
Royan Institute
Tehran, Tehran Province, Iran
Related Publications (1)
Moini A, Kiani K, Bahmanabadi A, Akhoond M, Akhlaghi A. Improvement in pregnancy rate by removal of cervical discharge prior to embryo transfer in ICSI cycles: a randomised clinical trial. Aust N Z J Obstet Gynaecol. 2011 Aug;51(4):315-20. doi: 10.1111/j.1479-828X.2011.01318.x. Epub 2011 Jun 9.
PMID: 21806579DERIVED
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Ashraf Moini Moini, MD
Academic staff of Endocrinology and Female Infertility Department, Royan Institute, Tehran - Iran
- PRINCIPAL INVESTIGATOR
Ladan Mohammadi yeganeh, MSc
Investigator
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER GOV
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 1, 2010
First Posted
July 2, 2010
Study Start
May 1, 2009
Primary Completion
May 1, 2010
Study Completion
May 1, 2010
Last Updated
September 21, 2011
Record last verified: 2010-07