Embryo Development in Microfluidics System of Culture
Comparison of the in Vitro Development of Human Embryos in Static and and Microfluidics Systems of Culture
1 other identifier
interventional
400
1 country
1
Brief Summary
Embryo culture is a cornerstone of in vitro fertilization treatments. Usually, embryos are cultured in microdrops of culture media in incubators with controlled temperature, humidity and atmosphere. However, these culture systems are static, while in vivo the initial growth of the embryo takes place in the uterine tube and they are submitted to a dynamic environment. The aim of this study is to compare the embryo development on days 2 and 3 of culture morphological features of embryos under static and dynamic(microfluidics) systems of culture.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_2
Started Oct 2009
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2009
CompletedFirst Submitted
Initial submission to the registry
October 27, 2009
CompletedFirst Posted
Study publicly available on registry
October 28, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2011
CompletedOctober 28, 2009
October 1, 2009
1 year
October 27, 2009
October 27, 2009
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Embryo morphology on days 2 and 3 of embryo culture according to the criteria described by Lucinda Veeck
Embryo culture for 3 days before transference to the uterus
Secondary Outcomes (1)
Implantation rate and pregnancy rate
24 month
Study Arms (2)
Static culture
ACTIVE COMPARATOREmbryos individually cultured in microdrops of 40 microliters of G-IVFplus series V
Smart plataform
EXPERIMENTALEmbryos culture in dynamics microfluidic culture system
Interventions
Embryos will be cultured in a dynamic system of microfluidics.
Embryos cultured in 40 microliters microdrops of G-IVF plus series V
Eligibility Criteria
You may qualify if:
- Age between 21 and 35 years old
- No more than 1 previous IVF failure
- Absence of physical conditions that can interfere in oocyte quality
- At least 8 zigotes 24 hours after fertilization
You may not qualify if:
- Use of epididimary or testicular sperm
- Sperm or egg donation
- Untreated systemic diseases
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Federal University of São Paulolead
- Incept Biosystemscollaborator
Study Sites (1)
Departamento de Ginecologia
São Paulo, São Paulo, 04023-900, Brazil
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Eduardo LA Motta, MD, PhD
Department of Gynecology - Universidade Federal de Sao Paulo
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- NONE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
October 27, 2009
First Posted
October 28, 2009
Study Start
October 1, 2009
Primary Completion
October 1, 2010
Study Completion
October 1, 2011
Last Updated
October 28, 2009
Record last verified: 2009-10