Neural Mechanisms in Asthma
Neural Mechanisms by Which Chronic Stress Regulates Inflammation in Asthma
1 other identifier
observational
31
1 country
1
Brief Summary
Asthma is a chronic disease that affects nearly 13% of adults in the U.S., causing substantial impairment that is reflected in the tens of millions of missed days of work, and doctors' and emergency room visits it leads to annually. Those who have asthma are twice as likely to develop depression and anxiety, which are associated with more frequent and severe asthma symptoms, especially in those under chronic stress. The project proposed here seeks to understand the role of the brain in these associations and to evaluate the neural mechanisms through which a safe, low-cost intervention, that influences the function of body via the mind, may diminish the expression of asthma symptoms.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Oct 2011
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 30, 2010
CompletedFirst Posted
Study publicly available on registry
July 2, 2010
CompletedStudy Start
First participant enrolled
October 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2014
CompletedOctober 2, 2015
December 1, 2014
3.1 years
June 30, 2010
September 30, 2015
Conditions
Outcome Measures
Primary Outcomes (4)
Neural activity in response to stress
positron emission tomography
duration of stress (30 minutes)
inflammation
infiltration of eosinophils into lung sputum, percentage of blood eosinophils, exhaled nitric oxide, glucocorticoid sensitivity of peripheral blood leukocytes
24 hours
lung function
peak expiratory volume in 1 sec effort
24 hours
peripheral acute stress reactivity
salivary cortisol and alpha amylase in response to acute stressor
60 minutes
Study Arms (2)
Asthmatic, chronic stress
Asthmatic, non-stress
Eligibility Criteria
Community sample
You may qualify if:
- Asthmatics:
- Physician diagnosed asthma with previous use of asthma medication
- Controls:
- negative skin-prick test to cat dander or house dust mite and have no history of asthma
- Chronic Stress:
- score 3 or above on any subscale of the UCLA (University of California Los Angeles) chronic stress interview
- No chronic stress:
- score 1.5 or below on all subscales of the UCLA chronic stress interview
You may not qualify if:
- Individuals with severe asthma, or those whom currently require the use of corticosteroids
- Individuals with significant medical problems
- Individuals who smoke cigarettes
- Individuals a previous adverse reaction to corticosteroids, a recent (\< 1 month) viral illness, a history of severe asthma or anaphylaxis.
- Breastfeeding women or women who are, suspect they might be or are trying to become pregnant
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Wisconsin-Madison
Madison, Wisconsin, 53715, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 30, 2010
First Posted
July 2, 2010
Study Start
October 1, 2011
Primary Completion
November 1, 2014
Study Completion
November 1, 2014
Last Updated
October 2, 2015
Record last verified: 2014-12