Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Adolescent Smokers

NCT01148355 | Completed

• 2 other identifiers: 99990843508-DA-N435
• Study Type: observational
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

Background:

• Multiple social, psychological, and environmental factors contribute to adolescents' use of cigarettes. Environmental smoking cues have been shown to play an important role in the maintenance of nicotine addiction and in relapse to smoking. However, few studies have examined craving and cue-reactivity in adolescent smokers, even though craving appears to contribute to ongoing smoking and relapse in this age group.
• Another factor central to addiction is the rewarding effect of drugs, or the interaction between the person, the drug, and the environmental setting. However, more research is needed on whether environmental cues lead to increased smoking in adolescents. Objectives: \- To determine the effects of smoking versus neutral cues in adolescents who smoke on (1) craving, mood, and autonomic responsivity and (2) the relative reinforcing efficacy of tobacco cigarettes. Eligibility: \- Adolescents 12 to 17 years of age who are current smokers (at least five cigarettes per day for the past 6 months). Design:
• This study will involve three study visits. Participants will be allowed to smoke before all study sessions and will give a breath carbon monoxide (CO) sample before all sessions. Participants must not use any illicit drugs or alcohol 24 hours before sessions.
• Visit 1 (baseline session): Participants will provide a urine sample and will be familiarized with the study room and session design.
• Visits 2 and 3: Participants will be connected to physiological recording devices to measure heart rate, perspiration, and other physical responses. After baseline readings, participants will be exposed to smoking cues at one experimental session and to neutral cues at the other experimental session.
• Before, during, and after cue presentation, participants will complete self-report measures of mood and craving and have physiological measures taken. They will then be re-exposed to smoking or neutral cues and engage in a self-administration procedure to examine the effect of cues on the reinforcing efficacy of cigarettes.

Conditions

Nicotine Dependence

Keywords

Craving; Moods; Adolescents; Nicotine; Reinforcement

Eligibility Criteria

• Age: 13 Years - 17 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• year old males and females
• smoking at least 5 cigarettes per day for at least 6 months
• urinary cotinine level greater than or equal to 100 ng/ml (NicAlert(Registered Trademark) reading greater than or equal to 3)
• medically and psychologically healthy as determined by screening criteria.

You may not qualify if:

• current interest in reducing or quitting smoking
• treatment for nicotine dependence in the past 3 months
• use of nicotine replacement products, bupropion, or varenicline in the past 3 months
• alcohol and any illicit drug use more than 7 times in the last 14 days
• current use of any medication that would interfere with the protocol in the opinion of MAI
• pregnant, nursing, or become pregnant during the study

Sponsors & Collaborators

• National Institute on Drug Abuse (NIDA): lead

Study Sites (1)

National Institute on Drug Abuse, Biomedical Research Center (BRC)

Baltimore, Maryland, 21224, United States

Location

Related Publications (3)

• Bagot KS, Heishman SJ, Moolchan ET. Tobacco craving predicts lapse to smoking among adolescent smokers in cessation treatment. Nicotine Tob Res. 2007 Jun;9(6):647-52. doi: 10.1080/14622200701365178.

  PMID: 17558821 BACKGROUND

• Bickel WK, Hughes JR, DeGrandpre RJ, Higgins ST, Rizzuto P. Behavioral economics of drug self-administration. IV. The effects of response requirement on the consumption of and interaction between concurrently available coffee and cigarettes. Psychopharmacology (Berl). 1992;107(2-3):211-6. doi: 10.1007/BF02245139.

  PMID: 1615122 BACKGROUND

• Corrigall WA. Nicotine self-administration in animals as a dependence model. Nicotine Tob Res. 1999 Mar;1(1):11-20. doi: 10.1080/14622299050011121.

  PMID: 11072385 BACKGROUND

MeSH Terms

Conditions

Tobacco Use Disorder

Condition Hierarchy (Ancestors)

Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH

Study Record Dates

• First Submitted: June 19, 2010
• First Posted: June 22, 2010
• Study Start: June 10, 2008
• Study Completion: January 14, 2011
• Last Updated: July 2, 2017

Record last verified: 2011-01-14

Locations

US (1)