The Contribution of Lp-PLA2 Level to the Presence of Coronary Plaques in Patients With Non Alcoholic Fatty Liver Disease

NCT01139632 | Unknown DMC

• 1 other identifier: 0030-10
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The most common cause of death in patients with NAFLD(Nonalcoholic Fatty Liver Disease) is CAD(Coronary Artery Disease). NAFLD patients have 65% more mortality than general population. The aim of the investigators study is to diagnose early coronary artery disease in NAFLD patient by measuring of PLA2. The investigators expect that PLA2 will higher in patients with patients with combination of CAD, unstable plaque and NAFLD.

Conditions

Nonalcoholic Fatty Liver Disease; Coronary Artery Disease

Keywords

NAFLD; lP-pla2; Coronary Arthery Disease

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

1. Patients at intermediate risk for significant CAD was admitted to the hospital with the diagnosis of chest pain or undergoing elective CT coronarography due to suspection of coronary artery disease. 2. Male and female 18years or older. Intermediate Risk patients for having significant CAD is defined as: a - chest pain or dyspnea in the presence of negative stress tests; b - the absence of chest pain but positive stress tests; c - the absence of chest pain and of positive stress tests but intermittent arrhythmias. Age \<18 years.

You may qualify if:

• Patients at intermediate risk for significant CAD was admitted to the hospital with the diagnosis of chest pain or undergoing elective CT coronarography due to suspection of coronary artery disease.
• Male and female 18years or older.
• Able to provide written informed consent.
• Intermediate Risk patients for having significant CAD is defined as:
• chest pain or dyspnea in the presence of negative stress tests;
• the absence of chest pain but positive stress tests;
• the absence of chest pain and of positive stress tests but intermittent arrhythmias

You may not qualify if:

• Acute coronary syndrome presentation:
• ST segment deviation on ECG and/or
• Cardiac troponin elevation.
• Chest pain in combination with positive tests for myocardial ischemia
• Hemodynamic instability on presentation.
• Inability to write inform consent.
• Age \<18 years.
• Participation in an investigational study within the previous 30days.

Sponsors & Collaborators

• Ziv Hospital: lead

Study Sites (1)

Ziv medical center liver unit

Safed, Israel, 13100, Israel

Location

MeSH Terms

Conditions

Non-alcoholic Fatty Liver Disease; Coronary Artery Disease

Condition Hierarchy (Ancestors)

Fatty Liver; Liver Diseases; Digestive System Diseases; Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Officials

• Nimer Assy, MD

  ZIV MEDICAL CENTER, SAFED ISRAEL

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV

Study Record Dates

• First Submitted: June 6, 2010
• First Posted: June 8, 2010
• Study Start: July 1, 2010
• Primary Completion: January 1, 2011
• Study Completion: March 1, 2011
• Last Updated: April 6, 2011

Record last verified: 2010-06

Locations

IL (1)