Cognitive Rehabilitation of Blast Traumatic Brain Injury (TBI)
CRbTBI
1 other identifier
interventional
77
1 country
1
Brief Summary
The purpose of this study is to investigate the efficacy of a structured rehabilitation program on cognitive function and quality of life in individuals with blast-induced traumatic brain injury (bTBI).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Mar 2011
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 3, 2010
CompletedFirst Posted
Study publicly available on registry
June 7, 2010
CompletedStudy Start
First participant enrolled
March 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
June 30, 2025
CompletedApril 15, 2026
April 1, 2026
14.3 years
June 3, 2010
April 10, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Cognitive functioning
Scaled Score on the standardized neuropsychological testing
Ten weeks
Secondary Outcomes (1)
Daily functioning
Ten weeks
Study Arms (2)
Arm 1
EXPERIMENTALCognitive intervention
Arm 2
ACTIVE COMPARATOREducational intervention
Interventions
Cognitive rehabilitation treatment designed specifically to address the most common cognitive complaints in executive and memory function
Educational intervention is geared at personal management of TBI-related symptoms.
Eligibility Criteria
You may qualify if:
- Operation Enduring Freedom (OEF)/Operation Iraqi Freedom (OIF) active-duty personnel or Veterans exposed to blast
- Meets criteria for mild TBI
- loss of consciousness (LOC) of 30 min or less
- Age: 21- 50
You may not qualify if:
- Evidence of penetrating head injury
- History of previous neurological diagnosis
- History of previous psychotic disorder prior to the blast exposure
- Hearing or vision impairment
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Boston, Massachusetts, 02130-4817, United States
Related Publications (3)
Bogdanova Y, Verfaellie M. Cognitive sequelae of blast-induced traumatic brain injury: recovery and rehabilitation. Neuropsychol Rev. 2012 Mar;22(1):4-20. doi: 10.1007/s11065-012-9192-3. Epub 2012 Feb 17.
PMID: 22350691BACKGROUNDGilbert KS, Kark SM, Gehrman P, Bogdanova Y. Sleep disturbances, TBI and PTSD: Implications for treatment and recovery. Clin Psychol Rev. 2015 Aug;40:195-212. doi: 10.1016/j.cpr.2015.05.008. Epub 2015 Jun 3.
PMID: 26164549RESULTBogdanova Y, Yee MK, Ho VT, Cicerone KD. Computerized Cognitive Rehabilitation of Attention and Executive Function in Acquired Brain Injury: A Systematic Review. J Head Trauma Rehabil. 2016 Nov/Dec;31(6):419-433. doi: 10.1097/HTR.0000000000000203.
PMID: 26709580RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Yelena Bogdanova, PhD PhD
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- FED
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 3, 2010
First Posted
June 7, 2010
Study Start
March 1, 2011
Primary Completion
June 30, 2025
Study Completion
June 30, 2025
Last Updated
April 15, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will not share