Pathogenesis of Primary Spontaneous Pneumothorax

NCT01135004 | Unknown

• 1 other identifier: 200912060R
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Primary spontaneous pneumothorax most commonly occurs in young, tall, lean males. The estimated recurrence rate is 23-50% after the first episode and increases to 60% after the second pneumothorax. The pathogenesis of this benign disease remains unclear. Generally, rupture of the emphysematous change or blebs in the apex of the lung is considered as the cause of pneumothorax. The main purpose of this study is to investigate the molecular pathogenesis of blebs formation or emphysematous change of the lung in these young, healthy patients.

Conditions

Pneumothorax

Keywords

pneumothorax; thoracoscopy; pathogenesis; blebs; surgery

Study Arms (1)

Pneumothorax patients

Primary spontaneous pneumothorax patients undergoing thoracoscopic bullectomy

Procedure: Thoracoscopic bullectomy

Interventions

Thoracoscopic bullectomy PROCEDURE

Thoracoscopic wedge resection of the diseased lung

Also known as: Video-assisted thoracic surgery (VATS)

Pneumothorax patients

Eligibility Criteria

• Age: 14 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Primary spontaneous pneumothorax most commonly occurs in young, tall, lean males without underlying pulmonary disease.

You may qualify if:

• Age between 14 and 40 years
• Spontaneous pneumothorax
• Underwent bullectomy of the lung

You may not qualify if:

• With underlying lung disease

Sponsors & Collaborators

• National Taiwan University Hospital: lead
• National Taiwan University Hospital, Yun-Lin Branch: collaborator
• National Science and Technology Council, Taiwan: collaborator

Study Sites (1)

National Taiwan University Hospital

Taipei, Taiwan, 100, Taiwan

RECRUITING

Related Publications (1)

• Ayed AK, Chandrasekaran C, Sukumar M. Video-assisted thoracoscopic surgery for primary spontaneous pneumothorax: clinicopathological correlation. Eur J Cardiothorac Surg. 2006 Feb;29(2):221-5. doi: 10.1016/j.ejcts.2005.11.005. Epub 2005 Dec 20.

  PMID: 16376095 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Thoracoscopic bullectomy will be performed in spontaneous pneumothorax patients. Part of the surgcal specimen (lung tissue) will be obtained for RNA and protein analyses.

MeSH Terms

Conditions

Pneumothorax; Blister

Interventions

Thoracic Surgery, Video-Assisted

Condition Hierarchy (Ancestors)

Pleural Diseases; Respiratory Tract Diseases; Skin Diseases, Vesiculobullous; Skin Diseases; Skin and Connective Tissue Diseases; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Thoracoscopy; Endoscopy; Diagnostic Techniques, Surgical; Diagnostic Techniques and Procedures; Diagnosis; Video-Assisted Surgery; Minimally Invasive Surgical Procedures; Surgical Procedures, Operative; Thoracic Surgical Procedures

Study Officials

• Yung-Chie Lee, MD, PhD

  National Taiwan University Hospital

  STUDY CHAIR

Central Study Contacts

Jin-Shing Chen, MD, PhD

CONTACT

886-2-23123456; chenjs@ntu.edu.tw

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 30, 2010
• First Posted: June 2, 2010
• Study Start: March 1, 2010
• Primary Completion: February 1, 2012
• Study Completion: February 1, 2013
• Last Updated: June 2, 2010

Record last verified: 2010-03

Locations

TW (1)