Disposal of Oral Fructose During Exercise

NCT01128647 | Completed

• 1 other identifier: Protocole 59/09
• Study Type: observational
• Target: 7
• Locations: 1 country
• Sites: 1

Brief Summary

There is evidence that total carbohydrate oxidation during exercise is higher after ingestion of fructose:glucose mixture than after ingestion of equimolar amounts of glucose alone. This may possible contribute to improve performance, provided that the extra carbohydrate oxidation induced by fructose:glucose co-ingestion occurs in skeletal muscle. The present study aims at assessing the hypothesis that, during exercise, a substantial portion of oral fructose is converted into lactate prior to oxidation To identify the major pathways of fructose disposal, 7 healthy endurance trained male volunteers will be studied. For each participant the following measurement will be performed

• a measurement of maximal oxygen consumption (VO2 max) on an ergometric bicycle
• a 2 hour exercise protocol with oral administration of a glucose drink. 6,6-2H2 glucose (0.44 µmol/kg/min) and 13C3 lactate (2.25 µmol/kg/min) will be infused to calculate glucose and lactate kinetics. Indirect calorimetry will be performed to measure total carbohydrate oxidation and expired 13CO2 will be monitored to calculate whole body lactate oxidation
• a 2 hour exercise protocol with oral administration of a glucose:fructose (72 + 48 g every hour) mixture. 6,6-2H2 glucose (0.44 µmol/kg/min) and 13C3 lactate (2.25 µmol/kg/min) will be infused to calculate glucose and lactate kinetics. Indirect calorimetry will be performed to measure total carbohydrate oxidation and expired 13CO2 will be monitored to calculate whole body lactate oxidation
• a 2 hour exercise protocol with oral administration of a glucose:fructose (72 + 48 g every hour) mixture with fructose labelled with 13C6 fructose to evaluate exogenous fructose metabolic fate and oxidation. 6,6-2H2 glucose (0.44 µmol/kg/min) will be infused to calculate glucose kinetics. Fructose conversion into lactate and glucose will be evaluated by monitoring the systemic appearance of plasma 13C-labelled lactate and 13C-labelled glucose. Total exogenous fructose oxidation will be measured by monitoring 13CO2 production. Based on these measurements, semi-quantitative estimates of total fructose oxidation, fructose conversion into glucose, fructose conversion into lactate, and oxidation of fructose-derived lactate will be obtained

Conditions

Carbohydrate Metabolism at Exercise

Outcome Measures

Primary Outcomes (1)

• Fructose conversion into lactate

  during a 2 hour-exercise at 60% VO2 max

Secondary Outcomes (3)

• Total exogenous fructose oxidation

  during a 2 hour-exercise at 60% VO2 max

• Fructose conversion into glucose

  during a 2 hour-exercise at 60% VO2 max

• Oxidation of lactate derived from fructose

  during a 2 hour-exercise at 60% VO2 max

Interventions

Fructose:glucose drink DIETARY_SUPPLEMENT

glucose drink DIETARY_SUPPLEMENT

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Healthy, endurance trained male volunteers

You may qualify if:

• age between 18 and 35 years
• males
• good physical health
• weekly cycling training sessions (\> 3 sessions/week)

You may not qualify if:

• diabetes or glucose intolerance
• past history of heart disease
• alcohol intake \> 30 g/day
• smokers
• drug consumption

Sponsors & Collaborators

• University of Lausanne: lead

Study Sites (1)

Centre Hospitalier Universitaire Vaudois

Lausanne, CH-1011, Switzerland

Location

Related Publications (1)

• Lecoultre V, Benoit R, Carrel G, Schutz Y, Millet GP, Tappy L, Schneiter P. Fructose and glucose co-ingestion during prolonged exercise increases lactate and glucose fluxes and oxidation compared with an equimolar intake of glucose. Am J Clin Nutr. 2010 Nov;92(5):1071-9. doi: 10.3945/ajcn.2010.29566. Epub 2010 Sep 8.

  PMID: 20826630 DERIVED

Study Design

• Study Type: observational
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Physiology

Study Record Dates

• First Submitted: May 21, 2010
• First Posted: May 24, 2010
• Study Start: April 1, 2009
• Primary Completion: December 1, 2009
• Study Completion: March 1, 2010
• Last Updated: February 13, 2013

Record last verified: 2013-02

Locations

CH (1)