Evaluation the Intracranial Volume Pressure Response in Increased Intracranial Pressure
Evaluation of the Intracranial Volume Pressure Relationship in Increased Intracranial Pressure Patients by a Mathematic Manner
1 other identifier
observational
41
1 country
1
Brief Summary
The purpose of this study is to discover a mathematic equation to express the intracranial pressure-volume (P-V) curve and a single indicator to reflect the status of the curve.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Dec 2008
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2010
CompletedFirst Submitted
Initial submission to the registry
May 18, 2010
CompletedFirst Posted
Study publicly available on registry
May 20, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2010
CompletedMay 24, 2010
May 1, 2010
1.2 years
May 18, 2010
May 20, 2010
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
intracranial pressure
The ICP values were obtained from the bedside ICU monitor. Once the ICP values exceed 20-25 mmHg, 1 ml of CSF was withdrawn from EVD and the corresponding change of ICP value was recorded. The withdrawn drainage of CSF continued until the final ICP value declined to 10 mmHg and the whole drainage procedure was completed within one minute.
one minute.
Study Arms (1)
All subjects act as their own contral
Interventions
Once the ICP exceed 20-25 mmHg, 1 ml of CSF was withdrawn from EVD and the corresponding change of ICP value was recorded. The withdrawn drainage of CSF continued until the final ICP value declined to 10 mmHg.
Eligibility Criteria
over 30 patients with severe brain injury and underwent bilateral external ventricular drainage in situ.
You may qualify if:
- Patients with severe brain damage
- Underwent bilateral external ventricular drainage (EVD)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Neurosurgery,Chang Gung Memorial Hospital
Taoyuan District, 333, Taiwan
Related Publications (1)
Lai HY, Lee CY, Hsu HH, Lee ST. The intracranial volume pressure response in increased intracranial pressure patients: Part 1. Calculation of the volume pressure indicator. Acta Neurochir (Wien). 2012 Dec;154(12):2271-5; discussion 2275. doi: 10.1007/s00701-010-0765-8. Epub 2010 Aug 18.
PMID: 20714759DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Shih-Tseng Lee, MD
Department of Neurosurgery,Chang Gung Memorial Hospital
- PRINCIPAL INVESTIGATOR
Hung-Yi Lai, MD
Department of Neurosurgery,Chang Gung Memorial Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
May 18, 2010
First Posted
May 20, 2010
Study Start
December 1, 2008
Primary Completion
February 1, 2010
Study Completion
June 1, 2010
Last Updated
May 24, 2010
Record last verified: 2010-05