Contrast Echocardiography in Non-ST Elevation Myocardial Infarction

NCT01122069 | Completed

• 2 other identifiers: MCE-NSTEMIREK237.07
• Study Type: observational
• Target: 110
• Locations: 1 country
• Sites: 1

Brief Summary

In patients with acute myocardial infarction, treatment logistics are primarily defined based upon ST segment shift in the electrocardiogram. While patients with ST elevation (STEMI) are forwarded to immediate coronary angiography and percutaneous coronary intervention, patients without ST elevation (NSTEMI) are initially medically treated and recommended coronary angiography within 48-72 hours. Early invasive treatment has been found cost-effective in intermediate and high-risk NSTEMI patients and current guidelines recommend use of the Thrombolysis in Myocardial Infarction (TIMI) risk score to identify patients who will benefit from early intervention due to high risk of new infraction and cardiovascular death. However, new research has suggested that TIMI risk score may not always identify patients with severe angiographic disease. The purpose of this study was to assess if contrast echocardiography could be used to identify NSTEMI patients with angiographically severe disease independent of their TIMI risk score.

Conditions

Non-ST-Elevation Myocardial Infarction

Study Arms (1)

Contrast echocardiography

110 patients with acute non-ST elevation myocardial infarct were examined with contrast echocardiography prior to coronary angiography.

Other: Perflutren Lipid Microsphere ultrasound contrast

Interventions

Perflutren Lipid Microsphere ultrasound contrast OTHER

Perflutren Lipid Microsphere ultrasound contrast 0.01 ml/kg administered as intravenous bolus

Also known as: Luminity

Contrast echocardiography

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

110 patients with acute non-ST elevation myocardial infarction

You may qualify if:

• acute non-ST elevation myocardial infarction

You may not qualify if:

• hemodynamic unstable
• mechanical prosthetic heart valve
• severly reduced pulmonary function

Sponsors & Collaborators

• University of Bergen: lead
• Haukeland University Hospital: collaborator

Study Sites (1)

Department of Heart Disease, Haukeland University Hospital

Bergen, Norway

Location

Related Publications (2)

• Eskerud I, Gerdts E, Nordrehaug JE, Lonnebakken MT. Global Coronary Artery Plaque Area is Associated with Myocardial Hypoperfusion in Women with Non-ST Elevation Myocardial Infarction. J Womens Health (Larchmt). 2015 May;24(5):367-73. doi: 10.1089/jwh.2014.4920. Epub 2015 Feb 18.

  PMID: 25692527 DERIVED

• Lonnebakken MT, Nordrehaug JE, Gerdts E. No gender difference in the extent of myocardial ischemia in non-ST elevation myocardial infarction. Eur J Prev Cardiol. 2014 Jan;21(1):123-9. doi: 10.1177/2047487312454107. Epub 2012 Jul 2.

  PMID: 22752464 DERIVED

MeSH Terms

Conditions

Non-ST Elevated Myocardial Infarction

Interventions

perflutren

Condition Hierarchy (Ancestors)

Myocardial Infarction; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• Mai Tone Lønnebakken, MD

  University of Bergen, Bergen, Norway

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Cardiology

Study Record Dates

• First Submitted: May 10, 2010
• First Posted: May 12, 2010
• Study Start: March 1, 2008
• Primary Completion: July 1, 2009
• Study Completion: July 1, 2009
• Last Updated: June 15, 2025

Record last verified: 2025-06

Locations

NO (1)