Hämeenlinna Metabolic Syndrome Research Program: Oxidized LDL and Arterial Elasticity in Metabolic Syndrome and Controls (HMS-01)

NCT01114763 | Completed

• 1 other identifier: KHMetS-01-AP
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 2

Brief Summary

Mechanisms that link metabolic syndrome to atherosclerosis are incompletely understood. As a part of Hämeenlinna Metabolic Syndrome Research Program (HMS), 40 men with metabolic syndrome and their 40 physically active controls (age: 30 to 65 years) are compared in a cross-sectional study. Except routine laboratory parameters, arterial elasticity and levels of oxidized LDL are determined. Study hypothesis: Levels of oxidized LDL and findings in arterial elasticity may differ between subjects with metabolic syndrome and controls explaining the elevated risk for cardiovascular diseases among patients with metabolic syndrome.

Conditions

Metabolic Syndrome

Keywords

Metabolic Syndrome; Oxidized Low Density Lipoprotein; Arterial Elasticity; Diabetes Mellitus; Cardiovascular Diseases

Study Arms (2)

Metabolic syndrome

40 men with metabolic syndrome

Control

40 physically active men

Eligibility Criteria

• Age: 30 Years - 65 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Primary care clinic.

You may qualify if:

• Group 1: Metabolic syndrome
• Finnish men with metabolic syndrome (MetS) defined according to National Cholesterol Education Program (NCEP) Adult Treatment Panel III
• MetS diagnosed in routine health examination and laboratory tests
• Age: 30 to 65 years
• Group 2: Control
• age-matched men
• Exercise physically more than three times a week and more than 30 minutes per exercise on regular basis
• Never been studied or treated because of cardiovascular disease

You may not qualify if:

• Cholesterol-lowering medication
• ACE-inhibitor medication
• Angiotensin-receptor blocker medication

Sponsors & Collaborators

• Kanta-Häme Central Hospital: lead
• Linnan Klinikka Oy: collaborator

Study Sites (2)

Linnan Klinikka

Hämeenlinna, 13100, Finland

Location

Central Hospital of Kanta-Häme

Hämeenlinna, 13530, Finland

Location

Related Publications (1)

• Pohjantahti-Maaroos H, Palomaki A, Kankkunen P, Laitinen R, Husgafvel S, Oksanen K. Circulating oxidized low-density lipoproteins and arterial elasticity: comparison between men with metabolic syndrome and physically active counterparts. Cardiovasc Diabetol. 2010 Aug 20;9:41. doi: 10.1186/1475-2840-9-41.

  PMID: 20727144 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum, EDTA plasma, citrate plasma

MeSH Terms

Conditions

Metabolic Syndrome; Diabetes Mellitus; Cardiovascular Diseases

Condition Hierarchy (Ancestors)

Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Officials

• Ari K Palomäki, MD PhD

  Central Hospital of Kanta-Häme

  STUDY DIRECTOR

• Kalevi Oksanen, MD PhD

  Central Hospital of Kanta-Häme

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV

Study Record Dates

• First Submitted: April 30, 2010
• First Posted: May 3, 2010
• Study Start: June 1, 2003
• Primary Completion: November 1, 2005
• Study Completion: September 1, 2007
• Last Updated: May 4, 2010

Record last verified: 2010-04

Locations

FI (2)