Assessing The Treatment Effect in Metabolic Syndrome Without Perceptible diabeTes (ATTEMPT)

NCT00416741 | Completed DMC

• 1 other identifier: HAS-01-231206
• Study Type: observational
• Target: 2,000
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this protocol is to improve awareness, treatment, and control of metabolic syndrome, within primary prevention of cardiovascular disease, by implementing guidelines, after training of the participating physicians.

Conditions

Metabolic Syndrome

Keywords

Metabolic Syndrome; Obesity; Hyperlipidemia; High blood pressure; Diabetes

Study Arms (2)

1 Usual Care-Lifestyle counseling

Metabolic syndrome

Behavioral: Implementation of guidelines

2 Intensive care-Lifestyle counseling

Metabolic Syndrome Implementation of guidelines

Behavioral: Implementation of guidelines

Interventions

Implementation of guidelines BEHAVIORAL

Attaining targets for LDL cholesterol, arterial blood pressure, fasting \[plasma flucose

1 Usual Care-Lifestyle counseling; 2 Intensive care-Lifestyle counseling

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Metabolic Syndrome (NCEP ATP III Definition modified to AHA/NHLBI definition)

You may qualify if:

• Metabolic Syndrome (NCEP ATP III Definition modified to AHA/NHLBI definition)

You may not qualify if:

• Pregnancy
• Lactation
• Malignancies with small life expectancy
• Unwillingness to participate

Sponsors & Collaborators

• Hellenic Atherosclerosis Society: lead

Study Sites (1)

Hellenic Atherosclerosis Society

Thessaloniki, Thessaloniki, 55132, Greece

Location

Related Publications (7)

• Athyros VG, Ganotakis ES, Elisaf MS, Liberopoulos EN, Goudevenos IA, Karagiannis A; GREECE-METS Collaborative Group. Prevalence of vascular disease in metabolic syndrome using three proposed definitions. Int J Cardiol. 2007 Apr 25;117(2):204-10. doi: 10.1016/j.ijcard.2006.04.078. Epub 2006 Jul 18.

  PMID: 16854482 BACKGROUND

• Daskalopoulou SS, Athyros VG, Kolovou GD, Anagnostopoulou KK, Mikhailidis DP. Definitions of metabolic syndrome: Where are we now? Curr Vasc Pharmacol. 2006 Jul;4(3):185-97. doi: 10.2174/157016106777698450.

  PMID: 16842136 BACKGROUND

• Athyros VG, Ganotakis ES, Bathianaki M, Monedas I, Goudevenos IA, Papageorgiou AA, Papathanasiou A, Kakafika AI, Mikhailidis DP, Elisaf M; MetS-Greece Collaborative Group. Awareness, treatment and control of the metabolic syndrome and its components: a multicentre Greek study. Hellenic J Cardiol. 2005 Nov-Dec;46(6):380-6.

  PMID: 16422124 BACKGROUND

• Athyros VG, Mikhailidis DP, Papageorgiou AA, Didangelos TP, Peletidou A, Kleta D, Karagiannis A, Kakafika AI, Tziomalos K, Elisaf M. Targeting vascular risk in patients with metabolic syndrome but without diabetes. Metabolism. 2005 Aug;54(8):1065-74. doi: 10.1016/j.metabol.2005.03.010.

  PMID: 16092057 BACKGROUND

• Athyros VG, Karagiannis A, Ganotakis ES, Paletas K, Nicolaou V, Bacharoudis G, Tziomalos K, Alexandrides T, Liberopoulos EN, Mikhailidis DP; Assessing The Treatment Effect in Metabolic syndrome without Perceptible diabeTes (ATTEMPT) Collaborative Group. Association between the changes in renal function and serum uric acid levels during multifactorial intervention and clinical outcome in patients with metabolic syndrome. A post hoc analysis of the ATTEMPT study. Curr Med Res Opin. 2011 Aug;27(8):1659-68. doi: 10.1185/03007995.2011.595782. Epub 2011 Jun 30.

  PMID: 21714711 DERIVED

• Athyros VG, Ganotakis E, Kolovou GD, Nicolaou V, Achimastos A, Bilianou E, Alexandrides T, Karagiannis A, Paletas K, Liberopoulos EN, Tziomalos K, Petridis D, Kakafika A, Elisaf MS, Mikhailidis DP; Assessing The Treatment Effect in Metabolic Syndrome Without Perceptible Diabetes (ATTEMPT) Collaborative. Assessing the treatment effect in metabolic syndrome without perceptible diabetes (ATTEMPT): a prospective-randomized study in middle aged men and women. Curr Vasc Pharmacol. 2011 Nov;9(6):647-57. doi: 10.2174/157016111797484080.

  PMID: 21476961 DERIVED

• Chimonas T, Athyros VG, Ganotakis E, Nicolaou V, Panagiotakos DB, Mikhailidis DP, Elisaf M; Assessing the Treatment Effect in Metabolic Syndrome Without Perceptible diabeTes (ATTEMPT) Collaborative Group. Cardiovascular risk factors and estimated 10-year risk of fatal cardiovascular events using various equations in Greeks with metabolic syndrome. Angiology. 2010 Feb-Mar;61(1):49-57. doi: 10.1177/0003319709351873.

  PMID: 20034959 DERIVED

Related Links

• PMID: 21476961-Assessing The Treatment Effect in Metabolic Syndrome without Perceptible Diabetes (ATTEMPT): A Prospective-Randomized Study in Middle Aged Men and Women.

MeSH Terms

Conditions

Metabolic Syndrome; Obesity; Hyperlipidemias; Hypertension; Diabetes Mellitus

Condition Hierarchy (Ancestors)

Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Overweight; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Dyslipidemias; Lipid Metabolism Disorders; Vascular Diseases; Cardiovascular Diseases; Endocrine System Diseases

Study Officials

• Vasilios G Athyros, MD

  Clinical Trials Chair of Hellenic Atherosclerosis Society

  STUDY CHAIR

• Moses - Elisaf, MD

  Clinical Trials Director of Hellenic Atherosclerosis Society

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: December 27, 2006
• First Posted: December 28, 2006
• Study Start: February 1, 2005
• Primary Completion: January 1, 2011
• Study Completion: February 1, 2011
• Last Updated: June 27, 2011

Record last verified: 2011-06

Locations

GR (1)