Efficacy and Safety of Humira® in Patients With Psoriatic Arthritis in Normal Medical Practice
A Long Term Documentation to Demonstrate Long Term Efficacy and Safety of Humira® in Patients With Psoriatic Arthritis Under Conditions of Daily Practice
1 other identifier
observational
4,635
1 country
509
Brief Summary
This study is a documentation of effectiveness and safety of Humira in patients with psoriatic arthritis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Aug 2005
Longer than P75 for all trials
509 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2005
CompletedFirst Submitted
Initial submission to the registry
February 26, 2010
CompletedFirst Posted
Study publicly available on registry
April 27, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2013
CompletedResults Posted
Study results publicly available
December 30, 2014
CompletedDecember 30, 2014
December 1, 2014
8.3 years
February 26, 2010
December 9, 2014
December 29, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (6)
Mean Change From Baseline in Disease Activity Score (DAS)28
The DAS28 is a validated index of rheumatoid arthritis disease activity. Twenty-eight tender joint counts, 28 swollen joint counts, C-reactive protein, and general health are included in the DAS28 score. Scores on the DAS28 range from 0 to 10. A DAS28 score greater than 5.1 indicates high disease activity, a DAS28 score less than 3.2 indicates low disease activity, and a DAS28 score less than 2.6 indicates clinical remission.
Baseline and Months 3, 6, 9, 12, 18, and 24
Mean Tender Joint Count (TJC) Over Time
Tender joint count represents the number of joints displaying tenderness. Although the DAS28 includes assessments of 28 joints, additional joints are typically evaluated in examinations of participants with Psoriatic Arthritis (PsA) as the joints typically affected in these participants differ from those commonly involved in Rheumatoid Arthritis (RA). Specifically, PsA often involves distal interphalangeal joints (DIP), whereas RA does not.
Baseline, and Months 3, 6, 9, 12, 18, and 24
Mean Swollen Joint Count (SJC) Over Time
Swollen joint count represents the number of joints displaying swelling. Although the DAS28 includes assessments of 28 joints, additional joints are typically evaluated in examinations of participants with Psoriatic Arthritis (PsA) as the joints typically affected in these participants differ from those commonly involved in Rheumatoid Arthritis (RA). Specifically, PsA often involves distal interphalangeal joints (DIP), whereas RA does not.
Baseline, and Months 3, 6, 9, 12, 18, and 24
Mean Percent Body Surface Area (BSA) Affected by Psoriasis Over Time
Body surface area was used to evaluate the extent of psoriatic skin involvement. At baseline, investigators classified participants as having BSA less than 3%, 3 to 10%, 11 to 20%, or greater than 20%. At all post-baseline time points, clinicians were asked to estimate BSA on a scale of 0% to 100% rather than as categories. BSA was visually determined by the investigator using the 'rule of nines' and estimating that the palm of the patient's hand was equal to 1% BSA.
Baseline, and Months 3, 6, 9, 12, 18, and 24
Mean Target Lesion Score (TLS) Over Time
The Target Lesion Score (TLS) was based on the severity of erythema, scaling, and infiltration of a prospectively-defined psoriasis target lesion of at least 2 cm in width that was considered to be representative of all other affected areas. Each of the three characteristics was evaluated by the clinician on a scale of 0 (absent) to 5 (maximal expression), and these scores were totaled to provide a TLS ranging from 0 (lowest severity) to 15 (highest severity).
Baseline, and Months 3, 6, 9, 12, 18, and 24
Number of Participants With Adverse Events (AEs)
Adverse Events (AEs) were reported that clinicians considered to be related to the study drug. An AE was considered to be a serious adverse event (SAE) if any of the following criteria were met: Death of participant, life-threatening event, hospitalization, prolongation of hospitalization, congenital anomaly, persistent or significant disability or incapacity, important medical event requiring medical or surgical intervention to prevent serious outcome, or spontaneous or elective abortion.
Baseline up to 24 months
Secondary Outcomes (13)
Number of Participants by Severity of Enthesitis Over Time
Baseline, and Months 3, 6, 9, 12, 18, and 24
Number of Participants by Severity of Dactylitis Over Time
Baseline, and Months 3, 6, 9, 12, 18, and 24
Number of Participants by Severity of Nail Psoriasis Levels Over Time
Baseline, and Months 3, 6, 9, 12, 18, and 24
Mean Erythrocyte Sedimentation Rate (ESR) Over Time
Baseline, and Months 3, 6, 9, 12, 18, and 24
Mean C-Reactive Protein (CRP) Levels Over Time
Baseline, and Months 3, 6, 9, 12, 18, and 24
- +8 more secondary outcomes
Study Arms (1)
Psoriatic Arthritis
Participants with Psoriatic Arthritis prescribed adalimumab in routine clinical practice were observed from the first dose for up to 24 months.
Eligibility Criteria
Clinical routine patients with psoriatic arthritis
You may qualify if:
- years of age or older (younger patients may be enrolled at the discretion of physician)
- Diagnosis of Psoriatic Arthritis (or any indication at the discretion of physician) and initiating adalimumab therapy
- Signed/dated Informed Consent
You may not qualify if:
- None
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (509)
Site Reference ID/Investigator# 35035
Aachen, 52062, Germany
Site Reference ID/Investigator# 64288
Aachen, 52062, Germany
Site Reference ID/Investigator# 35509
Ahlen, 59227, Germany
Site Reference ID/Investigator# 53118
Ahrensburg, 22926, Germany
Site Reference ID/Investigator# 35042
Altenburg, 04600, Germany
Site Reference ID/Investigator# 35045
Altenholz, 24161, Germany
Site Reference ID/Investigator# 35048
Amberg, 92224, Germany
Site Reference ID/Investigator# 96243
Annaberg-Buchholz, 9456, Germany
Site Reference ID/Investigator# 53205
Arnstadt, 99310, Germany
Site Reference ID/Investigator# 53091
Artern, 06556, Germany
Site Reference ID/Investigator# 33348
Augsburg, 86150, Germany
Site Reference ID/Investigator# 33357
Bad Abbach, 93077, Germany
Site Reference ID/Investigator# 35085
Bad Aibling, 83043, Germany
Site Reference ID/Investigator# 57895
Bad Aibling, 83043, Germany
Site Reference ID/Investigator# 91097
Bad Bentheim, 48455, Germany
Site Reference ID/Investigator# 35524
Bad Bentheim, D-48455, Germany
Site Reference ID/Investigator# 35572
Bad Bramstedt, 24576, Germany
Site Reference ID/Investigator# 64304
Bad Bramstedt, 24576, Germany
Site Reference ID/Investigator# 33371
Bad Endbach, 35080, Germany
Site Reference ID/Investigator# 53278
Bad Endbach, 63065, Germany
Site Reference ID/Investigator# 91084
Bad Homburg, 61348, Germany
Site Reference ID/Investigator# 33377
Bad Iburg, 49186, Germany
Site Reference ID/Investigator# 33381
Bad Iburg, 49186, Germany
Site Reference ID/Investigator# 53068
Bad Kissingen, 97688, Germany
Site Reference ID/Investigator# 33386
Bad Kreuznach, 55543, Germany
Site Reference ID/Investigator# 35574
Bad Kreuznach, 55543, Germany
Site Reference ID/Investigator# 33390
Bad Liebenwerda, 04924, Germany
Site Reference ID/Investigator# 33395
Bad Münder am Deister, 31848, Germany
Site Reference ID/Investigator# 96245
Bad Münder am Deister, 31848, Germany
Site Reference ID/Investigator# 91094
Bad Nauheim, 61231, Germany
Site Reference ID/Investigator# 35577
Bad Neuenahr, 53474, Germany
Site Reference ID/Investigator# 53181
Bad Neuenahr, 53474, Germany
Site Reference ID/Investigator# 57885
Bad Oeynhausen, 32545, Germany
Site Reference ID/Investigator# 33403
Bad Rappenau, 74906, Germany
Site Reference ID/Investigator# 53060
Bad Salzungen, 36433, Germany
Site Reference ID/Investigator# 91079
Bad Salzungen, 36433, Germany
Site Reference ID/Investigator# 53254
Bad Schlema, 8301, Germany
Site Reference ID/Investigator# 33416
Bad Staffelstein, 96231, Germany
Site Reference ID/Investigator# 33420
Bad Sülze, 18334, Germany
Site Reference ID/Investigator# 57890
Bad Tölz, 83646, Germany
Site Reference ID/Investigator# 33424
Baden-Baden, 76530, Germany
Site Reference ID/Investigator# 33428
Bamberg, 96047, Germany
Site Reference ID/Investigator# 33434
Bautzen, 02625, Germany
Site Reference ID/Investigator# 33437
Bautzen, 02625, Germany
Site Reference ID/Investigator# 53231
Bayreuth, 95444, Germany
Site Reference ID/Investigator# 33441
Bayreuth, 95445, Germany
Site Reference ID/Investigator# 33445
Bayreuth, 95445, Germany
Site Reference ID/Investigator# 68595
Bergen, 18528, Germany
Site Reference ID/Investigator# 33459
Berlin, 10117, Germany
Site Reference ID/Investigator# 35087
Berlin, 10117, Germany
Site Reference ID/Investigator# 53058
Berlin, 10117, Germany
Site Reference ID/Investigator# 53241
Berlin, 10117, Germany
Site Reference ID/Investigator# 53242
Berlin, 10117, Germany
Site Reference ID/Investigator# 33647
Berlin, 10178, Germany
Site Reference ID/Investigator# 57909
Berlin, 10178, Germany
Site Reference ID/Investigator# 53061
Berlin, 10243, Germany
Site Reference ID/Investigator# 53059
Berlin, 10369, Germany
Site Reference ID/Investigator# 68842
Berlin, 10369, Germany
Site Reference ID/Investigator# 33657
Berlin, 10435, Germany
Site Reference ID/Investigator# 53105
Berlin, 10709, Germany
Site Reference ID/Investigator# 98535
Berlin, 10713, Germany
Site Reference ID/Investigator# 34245
Berlin, 10719, Germany
Site Reference ID/Investigator# 33682
Berlin, 10777, Germany
Site Reference ID/Investigator# 68594
Berlin, 10827, Germany
Site Reference ID/Investigator# 34268
Berlin, 10961, Germany
Site Reference ID/Investigator# 33654
Berlin, 12159, Germany
Site Reference ID/Investigator# 64284
Berlin, 12159, Germany
Site Reference ID/Investigator# 35596
Berlin, 12161, Germany
Site Reference ID/Investigator# 35600
Berlin, 12161, Germany
Site Reference ID/Investigator# 53081
Berlin, 12353, Germany
Site Reference ID/Investigator# 53244
Berlin, 12435, Germany
Site Reference ID/Investigator# 91075
Berlin, 12435, Germany
Site Reference ID/Investigator# 64287
Berlin, 12437, Germany
Site Reference ID/Investigator# 34261
Berlin, 12681, Germany
Site Reference ID/Investigator# 33686
Berlin, 13055, Germany
Site Reference ID/Investigator# 64286
Berlin, 13407, Germany
Site Reference ID/Investigator# 52990
Berlin, 13507, Germany
Site Reference ID/Investigator# 52995
Berlin, 13507, Germany
Site Reference ID/Investigator# 35549
Berlin, 13595, Germany
Site Reference ID/Investigator# 53090
Berlin, 14129, Germany
Site Reference ID/Investigator# 35553
Berlin, 14163, Germany
Site Reference ID/Investigator# 57893
Berlin-Weissensee, 13086, Germany
Site Reference ID/Investigator# 35555
Bernau, 16321, Germany
Site Reference ID/Investigator# 53213
Bernsbach, 8315, Germany
Site Reference ID/Investigator# 34274
Beverungen, 37688, Germany
Site Reference ID/Investigator# 53085
Bietigheim-Bissingen, 74321, Germany
Site Reference ID/Investigator# 53268
Bietigheim-Bissingen, 74321, Germany
Site Reference ID/Investigator# 34284
Blankenburg/Hart, 38889, Germany
Site Reference ID/Investigator# 34287
Blaubeuren Abbey, 89143, Germany
Site Reference ID/Investigator# 34290
Bocholt, 46399, Germany
Site Reference ID/Investigator# 35640
Bochum, 44789, Germany
Site Reference ID/Investigator# 53196
Bochum, 44789, Germany
Site Reference ID/Investigator# 53179
Bochum, 44791, Germany
Site Reference ID/Investigator# 57908
Bochum, 44803, Germany
Site Reference ID/Investigator# 35643
Bogen, 94327, Germany
Site Reference ID/Investigator# 34301
Bonn, 53111, Germany
Site Reference ID/Investigator# 34295
Bonn, 53177, Germany
Site Reference ID/Investigator# 34306
Braunschweig, 38100, Germany
Site Reference ID/Investigator# 53234
Breitenbrunn, 08359, Germany
Site Reference ID/Investigator# 35608
Bremen, 28209, Germany
Site Reference ID/Investigator# 52987
Bremen, 28209, Germany
Site Reference ID/Investigator# 53107
Bremen, 28209, Germany
Site Reference ID/Investigator# 53247
Bremen, 28239, Germany
Site Reference ID/Investigator# 91073
Bremerhaven, 27572, Germany
Site Reference ID/Investigator# 34265
Buch, 13125, Germany
Site Reference ID/Investigator# 64291
Buch, 13125, Germany
Site Reference ID/Investigator# 68584
Burgstädt, 09217, Germany
Site Reference ID/Investigator# 81599
Chemnitz, 09119, Germany
Site Reference ID/Investigator# 34698
Chemnitz, 09126, Germany
Site Reference ID/Investigator# 57902
Chemnitz, 9116, Germany
Site Reference ID/Investigator# 35094
Chemnitz, D-09130, Germany
Site Reference ID/Investigator# 53262
Cologne, 50679, Germany
Site Reference ID/Investigator# 64298
Cologne, 50679, Germany
Site Reference ID/Investigator# 64293
Cologne, 50733, Germany
Site Reference ID/Investigator# 33988
Cologne, 50823, Germany
Site Reference ID/Investigator# 53193
Cologne, 50931, Germany
Site Reference ID/Investigator# 53071
Cologne, 50937, Germany
Site Reference ID/Investigator# 35236
Cologne, 51067, Germany
Site Reference ID/Investigator# 64300
Cologne, 51103, Germany
Site Reference ID/Investigator# 72857
Cologne, 51109, Germany
Site Reference ID/Investigator# 34710
Cottbus, 03046, Germany
Site Reference ID/Investigator# 53184
Cottbus, 3048, Germany
Site Reference ID/Investigator# 64303
Darmstadt, 64283, Germany
Site Reference ID/Investigator# 35620
Darmstadt, 64295, Germany
Site Reference ID/Investigator# 34724
Deggendorf, 94469, Germany
Site Reference ID/Investigator# 53209
Delmenhorst, 27749, Germany
Site Reference ID/Investigator# 53089
Delmenhorst, 27753, Germany
Site Reference ID/Investigator# 91077
Dinslaken, 46535, Germany
Site Reference ID/Investigator# 34741
Dortmund, 44147, Germany
Site Reference ID/Investigator# 35637
Dortmund, 44147, Germany
Site Reference ID/Investigator# 35633
Dortmund, 44263, Germany
Site Reference ID/Investigator# 57899
Dresden, 01067, Germany
Site Reference ID/Investigator# 35172
Dresden, 01097, Germany
Site Reference ID/Investigator# 34753
Dresden, 01109, Germany
Site Reference ID/Investigator# 53069
Dresden, 01219, Germany
Site Reference ID/Investigator# 34747
Dresden, 01277, Germany
Site Reference ID/Investigator# 34750
Dresden, 01277, Germany
Site Reference ID/Investigator# 34759
Dresden, 01277, Germany
Site Reference ID/Investigator# 68590
Dresden, 01277, Germany
Site Reference ID/Investigator# 53182
Dresden, 01307, Germany
Site Reference ID/Investigator# 91081
Dresden, 1109, Germany
Site Reference ID/Investigator# 68592
Dresden, 1217, Germany
Site Reference ID/Investigator# 57904
Dresden, 1309, Germany
Site Reference ID/Investigator# 34777
Duisburg, 47055, Germany
Site Reference ID/Investigator# 53072
Duisburg, 47249, Germany
Site Reference ID/Investigator# 98537
Duisburg, 47249, Germany
Site Reference ID/Investigator# 53266
Düren, 52349, Germany
Site Reference ID/Investigator# 34772
Düsseldorf, 40211, Germany
Site Reference ID/Investigator# 64302
Düsseldorf, 40225, Germany
Site Reference ID/Investigator# 34783
Eberswalde, 16225, Germany
Site Reference ID/Investigator# 53194
Eberswalde, 16225, Germany
Site Reference ID/Investigator# 53065
Eisenach, 99817, Germany
Site Reference ID/Investigator# 72856
Eisenach, 99817, Germany
Site Reference ID/Investigator# 53000
Eisleben Lutherstadt, 06295, Germany
Site Reference ID/Investigator# 35181
Elmshorn, 25335, Germany
Site Reference ID/Investigator# 53114
Eppstein, 65817, Germany
Site Reference ID/Investigator# 53221
Erftstadt, 50374, Germany
Site Reference ID/Investigator# 53070
Erfurt, 99084, Germany
Site Reference ID/Investigator# 53258
Erfurt, 99084, Germany
Site Reference ID/Investigator# 53259
Erfurt, 99084, Germany
Site Reference ID/Investigator# 57900
Erfurt, 99084, Germany
Site Reference ID/Investigator# 34808
Erfurt, 99096, Germany
Site Reference ID/Investigator# 35095
Erfurt, 99096, Germany
Site Reference ID/Investigator# 57901
Erkrath, 40699, Germany
Site Reference ID/Investigator# 34820
Erlangen, 91056, Germany
Site Reference ID/Investigator# 57896
Erlangen, D-91054, Germany
Site Reference ID/Investigator# 35195
Essen, 45326, Germany
Site Reference ID/Investigator# 35198
Essen, 45356, Germany
Site Reference ID/Investigator# 53219
Esslingen am Neckar, 73732, Germany
Site Reference ID/Investigator# 35201
Feldafing, 82340, Germany
Site Reference ID/Investigator# 35204
Flensburg, 24937, Germany
Site Reference ID/Investigator# 34832
Forchheim, 91301, Germany
Site Reference ID/Investigator# 35209
Frankenberg, 09669, Germany
Site Reference ID/Investigator# 64283
Frankfurt, 60590, Germany
Site Reference ID/Investigator# 34839
Frankfurt, 60596, Germany
Site Reference ID/Investigator# 35212
Fraureuth, 08427, Germany
Site Reference ID/Investigator# 91078
Frechen, 50226, Germany
Site Reference ID/Investigator# 35218
Freiberg, 09599, Germany
Site Reference ID/Investigator# 34853
Freiburg im Breisgau, 79098, Germany
Site Reference ID/Investigator# 34856
Freiburg im Breisgau, 79098, Germany
Site Reference ID/Investigator# 34860
Freiburg im Breisgau, 79106, Germany
Site Reference ID/Investigator# 35100
Freystadt, 92342, Germany
Site Reference ID/Investigator# 35223
Friedrichroda, 99894, Germany
Site Reference ID/Investigator# 68843
Garching, 85748, Germany
Site Reference ID/Investigator# 34878
Gelsenkirchen, 45881, Germany
Site Reference ID/Investigator# 68591
Gelsenkirchen, 45897, Germany
Site Reference ID/Investigator# 34882
Gera, 07545, Germany
Site Reference ID/Investigator# 57907
Gera, 07545, Germany
Site Reference ID/Investigator# 64285
Gera, 07545, Germany
Site Reference ID/Investigator# 64294
Gera, 07545, Germany
Site Reference ID/Investigator# 57897
Gera, 07548, Germany
Site Reference ID/Investigator# 53222
Gera, 7546, Germany
Site Reference ID/Investigator# 34886
Giessen, 35392, Germany
Site Reference ID/Investigator# 53116
Gornau, 09405, Germany
Site Reference ID/Investigator# 34895
Goslar, 38642, Germany
Site Reference ID/Investigator# 68589
Gotha, 99867, Germany
Site Reference ID/Investigator# 52998
Göttingen, 37075, Germany
Site Reference ID/Investigator# 35493
Gräfelfing, 82166, Germany
Site Reference ID/Investigator# 53224
Greifswald, 17489, Germany
Site Reference ID/Investigator# 57889
Greifswald, 17489, Germany
Site Reference ID/Investigator# 64289
Greifswald, 17489, Germany
Site Reference ID/Investigator# 34903
Greifswald, 17491, Germany
Site Reference ID/Investigator# 58122
Greifswald, 17491, Germany
Site Reference ID/Investigator# 53106
Gronau, 48599, Germany
Site Reference ID/Investigator# 91070
Großenhain, 01558, Germany
Site Reference ID/Investigator# 34911
Güstrow, 18273, Germany
Site Reference ID/Investigator# 34936
Halle, 06108, Germany
Site Reference ID/Investigator# 34939
Halle, 06108, Germany
Site Reference ID/Investigator# 53067
Halle, 06108, Germany
Site Reference ID/Investigator# 53236
Halle, 06108, Germany
Site Reference ID/Investigator# 81601
Halle, 06108, Germany
Site Reference ID/Investigator# 34921
Halle, 06112, Germany
Site Reference ID/Investigator# 34943
Halle, 06120, Germany
Site Reference ID/Investigator# 34931
Halle, 06128, Germany
Site Reference ID/Investigator# 53063
Hamburg, 20144, Germany
Site Reference ID/Investigator# 53183
Hamburg, 20246, Germany
Site Reference ID/Investigator# 96237
Hamburg, 20246, Germany
Site Reference ID/Investigator# 34969
Hamburg, 20251, Germany
Site Reference ID/Investigator# 53073
Hamburg, 20354, Germany
Site Reference ID/Investigator# 34951
Hamburg, 20355, Germany
Site Reference ID/Investigator# 53276
Hamburg, 21031, Germany
Site Reference ID/Investigator# 34957
Hamburg, 21075, Germany
Site Reference ID/Investigator# 96242
Hamburg, 21109, Germany
Site Reference ID/Investigator# 35451
Hamburg, 22081, Germany
Site Reference ID/Investigator# 53198
Hamburg, 22081, Germany
Site Reference ID/Investigator# 35113
Hamburg, 22087, Germany
Site Reference ID/Investigator# 35006
Hamburg, 22089, Germany
Site Reference ID/Investigator# 53186
Hamburg, 22089, Germany
Site Reference ID/Investigator# 53212
Hamburg, 22111, Germany
Site Reference ID/Investigator# 53206
Hamburg, 22119, Germany
Site Reference ID/Investigator# 34960
Hamburg, 22147, Germany
Site Reference ID/Investigator# 53199
Hamburg, 22147, Germany
Site Reference ID/Investigator# 35448
Hamburg, 22179, Germany
Site Reference ID/Investigator# 34954
Hamburg, 22415, Germany
Site Reference ID/Investigator# 34997
Hamburg, 22459, Germany
Site Reference ID/Investigator# 34993
Hamburg, 22523, Germany
Site Reference ID/Investigator# 53098
Hamburg, 22529, Germany
Site Reference ID/Investigator# 53279
Hamburg, 22529, Germany
Site Reference ID/Investigator# 72854
Hamburg, 22607, Germany
Site Reference ID/Investigator# 34982
Hamburg, 22609, Germany
Site Reference ID/Investigator# 34985
Hamburg, 22609, Germany
Site Reference ID/Investigator# 35110
Hamburg, 22609, Germany
Site Reference ID/Investigator# 53066
Hamburg, 22609, Germany
Site Reference ID/Investigator# 53248
Hamburg, 22761, Germany
Site Reference ID/Investigator# 34973
Hamburg, 22767, Germany
Site Reference ID/Investigator# 35018
Hanau, 63450, Germany
Site Reference ID/Investigator# 33711
Hanover, 30159, Germany
Site Reference ID/Investigator# 53100
Hanover, 30159, Germany
Site Reference ID/Investigator# 68582
Hanover, 30159, Germany
Site Reference ID/Investigator# 53083
Hanover, 30161, Germany
Site Reference ID/Investigator# 64301
Hanover, 30625, Germany
Site Reference ID/Investigator# 53256
Harrislee, 24955, Germany
Site Reference ID/Investigator# 33797
Heidelberg, 69120, Germany
Site Reference ID/Investigator# 33804
Heidelberg, 69120, Germany
Site Reference ID/Investigator# 35118
Heidelberg, 69120, Germany
Site Reference ID/Investigator# 91083
Heidelberg, 69120, Germany
Site Reference ID/Investigator# 33800
Heidelberg, 69121, Germany
Site Reference ID/Investigator# 33807
Heidelberg, 69121, Germany
Site Reference ID/Investigator# 33817
Heilbad Heiligenstadt, 37308, Germany
Site Reference ID/Investigator# 53057
Heilbad Heiligenstadt, 37308, Germany
Site Reference ID/Investigator# 64297
Herne, 44623, Germany
Site Reference ID/Investigator# 57894
Herrsching am Ammersee, 82211, Germany
Site Reference ID/Investigator# 68586
Herten, 45699, Germany
Site Reference ID/Investigator# 53272
Hildburghausen, 98646, Germany
Site Reference ID/Investigator# 53080
Hilden, 40721, Germany
Site Reference ID/Investigator# 53097
Hildesheim, 31124, Germany
Site Reference ID/Investigator# 33833
Hof, 95028, Germany
Site Reference ID/Investigator# 33841
Hofheim, 65719, Germany
Site Reference ID/Investigator# 114015
Hohen Neuendorf, 16540, Germany
Site Reference ID/Investigator# 33844
Hohenfelde, 18209, Germany
Site Reference ID/Investigator# 53084
Holzkirchen, 83607, Germany
Site Reference ID/Investigator# 53092
Homburg, 66424, Germany
Site Reference ID/Investigator# 91085
Homburg, 66424, Germany
Site Reference ID/Investigator# 53109
Hoyerswerda, 02977, Germany
Site Reference ID/Investigator# 33857
Immenstadt im Allgäu, 87509, Germany
Site Reference ID/Investigator# 98538
Ingoldstadt, 85049, Germany
Site Reference ID/Investigator# 33934
Ingolstadt, 85049, Germany
Site Reference ID/Investigator# 53111
Ingolstadt, 85049, Germany
Site Reference ID/Investigator# 53053
Jena, 07740, Germany
Site Reference ID/Investigator# 53055
Jena, 07743, Germany
Site Reference ID/Investigator# 5305
Jena, 07745, Germany
Site Reference ID/Investigator# 33941
Jülich, 52428, Germany
Site Reference ID/Investigator# 33945
Kahla, 07768, Germany
Site Reference ID/Investigator# 35123
Kahla, 07768, Germany
Site Reference ID/Investigator# 33949
Kaiserslautern, 67655, Germany
Site Reference ID/Investigator# 52992
Kamenz, 01917, Germany
Site Reference ID/Investigator# 33960
Karlsruhe, 76133, Germany
Site Reference ID/Investigator# 35483
Karlstadt am Main, 97753, Germany
Site Reference ID/Investigator# 53192
Kassel, 34117, Germany
Site Reference ID/Investigator# 33963
Kassel, 34131, Germany
Site Reference ID/Investigator# 33967
Katzhütte, 98746, Germany
Site Reference ID/Investigator# 53229
Kiel, 24105, Germany
Site Reference ID/Investigator# 72859
Kleinmachnow, 14532, Germany
Site Reference ID/Investigator# 53233
Koblenz, 56068, Germany
Site Reference ID/Investigator# 34001
Königs Wusterhausen, 15711, Germany
Site Reference ID/Investigator# 91076
Krefeld, 47798, Germany
Site Reference ID/Investigator# 91093
Krefeld, 47798, Germany
Site Reference ID/Investigator# 53108
Krefeld, 47802, Germany
Site Reference ID/Investigator# 34007
Kressbronn, 88079, Germany
Site Reference ID/Investigator# 34083
Kronach, 96317, Germany
Site Reference ID/Investigator# 53101
Kyritz, 16866, Germany
Site Reference ID/Investigator# 34004
Lahr, 77933, Germany
Site Reference ID/Investigator# 35244
Landau, 76829, Germany
Site Reference ID/Investigator# 64290
Langenfeld, 40764, Germany
Site Reference ID/Investigator# 53245
Leinefelde, 37327, Germany
Site Reference ID/Investigator# 53115
Leipzig, 04103, Germany
Site Reference ID/Investigator# 53087
Leipzig, 04109, Germany
Site Reference ID/Investigator# 34105
Leipzig, 04129, Germany
Site Reference ID/Investigator# 34108
Leipzig, 04207, Germany
Site Reference ID/Investigator# 53197
Leipzig, 04207, Germany
Site Reference ID/Investigator# 53052
Leipzig, 04289, Germany
Site Reference ID/Investigator# 53211
Leipzig, 04299, Germany
Site Reference ID/Investigator# 53088
Leverkusen, 51373, Germany
Site Reference ID/Investigator# 34122
Lichtenstein, 09350, Germany
Site Reference ID/Investigator# 53180
Lingen, 49809, Germany
Site Reference ID/Investigator# 35253
Lippstadt, 59555, Germany
Site Reference ID/Investigator# 96240
Löbau, 02708, Germany
Site Reference ID/Investigator# 35259
Ludwigsfelde, 14974, Germany
Site Reference ID/Investigator# 53195
Ludwigshafen, 67063, Germany
Site Reference ID/Investigator# 53249
Ludwigslust, 19288, Germany
Site Reference ID/Investigator# 53110
Lübeck, 23538, Germany
Site Reference ID/Investigator# 34135
Lübeck, 23564, Germany
Site Reference ID/Investigator# 53074
Lüdenscheid, 58515, Germany
Site Reference ID/Investigator# 96239
Lüneburg, 21335, Germany
Site Reference ID/Investigator# 34146
Magdeburg, 39104, Germany
Site Reference ID/Investigator# 34149
Magdeburg, 39104, Germany
Site Reference ID/Investigator# 91082
Magdeburg, 39104, Germany
Site Reference ID/Investigator# 64292
Magdeburg, 39108, Germany
Site Reference ID/Investigator# 68583
Magdeburg, 39108, Germany
Site Reference ID/Investigator# 53230
Magdeburg, 39120, Germany
Site Reference ID/Investigator# 64305
Magdeburg, 39124, Germany
Site Reference ID/Investigator# 53075
Mainz, 55131, Germany
Site Reference ID/Investigator# 68593
Mainz, 55131, Germany
Site Reference ID/Investigator# 34179
Mannheim, 68165, Germany
Site Reference ID/Investigator# 34191
Marktredwitz, 95615, Germany
Site Reference ID/Investigator# 34195
Marl, 45768, Germany
Site Reference ID/Investigator# 34199
Meissen, 01662, Germany
Site Reference ID/Investigator# 53269
Melsungen, 34212, Germany
Site Reference ID/Investigator# 53078
Memmingen, 87700, Germany
Site Reference ID/Investigator# 35284
Menz, 39175, Germany
Site Reference ID/Investigator# 35286
Minden, 32429, Germany
Site Reference ID/Investigator# 34207
Mittelherwigsdorf, 02763, Germany
Site Reference ID/Investigator# 57883
Moenkeburg, 24248, Germany
Site Reference ID/Investigator# 34217
Mönchengladbach, 41061, Germany
Site Reference ID/Investigator# 34212
Mönchengladbach, 41199, Germany
Site Reference ID/Investigator# 53095
Mönchengladbach, 41199, Germany
Site Reference ID/Investigator# 53261
Mönchengladbach, 41236, Germany
Site Reference ID/Investigator# 64282
Munich, 80634, Germany
Site Reference ID/Investigator# 34039
Munich, 80639, Germany
Site Reference ID/Investigator# 57892
Munich, 80802, Germany
Site Reference ID/Investigator# 64295
Munich, 80802, Germany
Site Reference ID/Investigator# 35294
Munich, 81377, Germany
Site Reference ID/Investigator# 34234
Munich, 81547, Germany
Site Reference ID/Investigator# 91080
Munich, 81667, Germany
Site Reference ID/Investigator# 34042
Munich, 81925, Germany
Site Reference ID/Investigator# 53270
Munich, D-81541, Germany
Site Reference ID/Investigator# 34223
Mühlhausen, 99974, Germany
Site Reference ID/Investigator# 35291
Mülheim, 45468, Germany
Site Reference ID/Investigator# 53235
Mülheim, 45468, Germany
Site Reference ID/Investigator# 34228
Müllheim, 79379, Germany
Site Reference ID/Investigator# 53062
Münster, 48143, Germany
Site Reference ID/Investigator# 68587
Münster, 48143, Germany
Site Reference ID/Investigator# 34047
Münster, 48149, Germany
Site Reference ID/Investigator# 53093
Münster, 48149, Germany
Site Reference ID/Investigator# 91096
Münster, 48149, Germany
Site Reference ID/Investigator# 53246
Naila, 95119, Germany
Site Reference ID/Investigator# 53271
Nastätten, 56355, Germany
Site Reference ID/Investigator# 35305
Naumburg, 06618, Germany
Site Reference ID/Investigator# 34051
Naunhof, 04683, Germany
Site Reference ID/Investigator# 34060
Neubrandenburg, 17033, Germany
Site Reference ID/Investigator# 34063
Neuburg am Inn, 86633, Germany
Site Reference ID/Investigator# 53220
Neunkirchen, 66538, Germany
Site Reference ID/Investigator# 35312
Neuss, 41460, Germany
Site Reference ID/Investigator# 34075
Neustadt, 67434, Germany
Site Reference ID/Investigator# 34079
Niefern-Öschelbronn, 75223, Germany
Site Reference ID/Investigator# 34157
Nienburg, 31582, Germany
Site Reference ID/Investigator# 57891
Nienburg, 31582, Germany
Site Reference ID/Investigator# 52997
Nordhausen, 99734, Germany
Site Reference ID/Investigator# 52999
Nordhausen, 99734, Germany
Site Reference ID/Investigator# 53277
Nordhausen, 99734, Germany
Site Reference ID/Investigator# 53054
Nuremberg, 90429, Germany
Site Reference ID/Investigator# 68588
Nuremberg, 90429, Germany
Site Reference ID/Investigator# 53112
Nuremberg, 90482, Germany
Site Reference ID/Investigator# 96244
Oberhausen, 46145, Germany
Site Reference ID/Investigator# 34172
Oelsnitz, 09376, Germany
Site Reference ID/Investigator# 53104
Oelsnitz, 09376, Germany
Site Reference ID/Investigator# 34175
Offenburg, 77652, Germany
Site Reference ID/Investigator# 33491
Oldenburg, 26121, Germany
Site Reference ID/Investigator# 57886
Oldenburg, 26133, Germany
Site Reference ID/Investigator# 91067
Oschatz, 04758, Germany
Site Reference ID/Investigator# 53207
Osnabrück, 49074, Germany
Site Reference ID/Investigator# 81600
Osnabrück, 49076, Germany
Site Reference ID/Investigator# 53228
Ostseebad Damp, 24351, Germany
Site Reference ID/Investigator# 35334
Paderborn, 33098, Germany
Site Reference ID/Investigator# 33507
Parchim, 19370, Germany
Site Reference ID/Investigator# 35339
Passau, 94032, Germany
Site Reference ID/Investigator# 72858
Peitz, 03185, Germany
Site Reference ID/Investigator# 53096
Petershagen, 32469, Germany
Site Reference ID/Investigator# 53086
Pinneberg, 25421, Germany
Site Reference ID/Investigator# 53232
Pirna, 01796, Germany
Site Reference ID/Investigator# 33522
Planegg, 82152, Germany
Site Reference ID/Investigator# 33527
Plauen, 08523, Germany
Site Reference ID/Investigator# 96278
Plochingen, 73207, Germany
Site Reference ID/Investigator# 33469
Potsdam, 14467, Germany
Site Reference ID/Investigator# 33465
Potsdam, 14469, Germany
Site Reference ID/Investigator# 96236
Potsdam, 14471, Germany
Site Reference ID/Investigator# 53281
Potsdam, 14480, Germany
Site Reference ID/Investigator# 33475
Prüm, 54595, Germany
Site Reference ID/Investigator# 33478
Püttlingen, 66346, Germany
Site Reference ID/Investigator# 53257
Püttlingen, 66346, Germany
Site Reference ID/Investigator# 91120
Püttlingen, 66346, Germany
Site Reference ID/Investigator# 53094
Quedlinburg, 06484, Germany
Site Reference ID/Investigator# 53265
Querfurt, 6268, Germany
Site Reference ID/Investigator# 33483
Radebeul, 01445, Germany
Site Reference ID/Investigator# 35346
Radebeul, 01445, Germany
Site Reference ID/Investigator# 53280
Ratingen, 40882, Germany
Site Reference ID/Investigator# 57888
Ratingen, 40882, Germany
Site Reference ID/Investigator# 33487
Ratzeburg, 23909, Germany
Site Reference ID/Investigator# 33889
Regensburg, 93049, Germany
Site Reference ID/Investigator# 57912
Regensburg, 93049, Germany
Site Reference ID/Investigator# 57911
Regensburg, 93051, Germany
Site Reference ID/Investigator# 53264
Regensburg, 93053, Germany
Site Reference ID/Investigator# 33901
Rendsburg, 24768, Germany
Site Reference ID/Investigator# 52991
Ribnitz-Damgarten, 18311, Germany
Site Reference ID/Investigator# 53267
Riesa, 01587, Germany
Site Reference ID/Investigator# 33910
Riesa, 01589, Germany
Site Reference ID/Investigator# 33913
Rinteln, 31737, Germany
Site Reference ID/Investigator# 33922
Rostock, 18059, Germany
Site Reference ID/Investigator# 33926
Rostock, 18059, Germany
Site Reference ID/Investigator# 33930
Rothenburg, 02929, Germany
Site Reference ID/Investigator# 53113
Rudolstadt, 07407, Germany
Site Reference ID/Investigator# 35361
Rüdersdorf, 15562, Germany
Site Reference ID/Investigator# 34015
Saarbrücken, 66111, Germany
Site Reference ID/Investigator# 91071
Saarlouis, 66740, Germany
Site Reference ID/Investigator# 35382
Saint Martin, 67487, Germany
Site Reference ID/Investigator# 34022
Salzwedel, 29410, Germany
Site Reference ID/Investigator# 34026
Sande, 26452, Germany
Site Reference ID/Investigator# 53208
Schleiz, 7907, Germany
Site Reference ID/Investigator# 91074
Schlettau, 09487, Germany
Site Reference ID/Investigator# 33533
Schneeberg, 08289, Germany
Site Reference ID/Investigator# 33538
Schramberg, 78713, Germany
Site Reference ID/Investigator# 33541
Schutterwald, 77746, Germany
Site Reference ID/Investigator# 35370
Schwandorf in Bayern, 92421, Germany
Site Reference ID/Investigator# 91072
Schwandorf in Bayern, 92421, Germany
Site Reference ID/Investigator# 57905
Schwedt, 16303, Germany
Site Reference ID/Investigator# 72855
Schweina, 36448, Germany
Site Reference ID/Investigator# 33548
Schwerin, 19053, Germany
Site Reference ID/Investigator# 35375
Schwerin, 19053, Germany
Site Reference ID/Investigator# 33554
Schwerte, 58239, Germany
Site Reference ID/Investigator# 33558
Seesen, 38723, Germany
Site Reference ID/Investigator# 33566
Sinsheim, 74889, Germany
Site Reference ID/Investigator# 33571
Soltau, 29614, Germany
Site Reference ID/Investigator# 53255
Spelle, 48480, Germany
Site Reference ID/Investigator# 33584
Stadtbergen, 86391, Germany
Site Reference ID/Investigator# 98539
Stolberg, 52222, Germany
Site Reference ID/Investigator# 53218
Storkow, 15859, Germany
Site Reference ID/Investigator# 53082
Straubing, 94315, Germany
Site Reference ID/Investigator# 33603
Stuttgart, 70178, Germany
Site Reference ID/Investigator# 33606
Stuttgart, 70178, Germany
Site Reference ID/Investigator# 33610
Stuttgart, 70199, Germany
Site Reference ID/Investigator# 33597
Stuttgart, 70372, Germany
Site Reference ID/Investigator# 53210
Suhl, 98527, Germany
Site Reference ID/Investigator# 53223
Suhl, 98527, Germany
Site Reference ID/Investigator# 35388
Suhl, 98529, Germany
Site Reference ID/Investigator# 33624
Torgelow, 17358, Germany
Site Reference ID/Investigator# 53077
Treuenbrietzen, 14929, Germany
Site Reference ID/Investigator# 57906
Treuenbrietzen, 14929, Germany
Site Reference ID/Investigator# 53200
Tuttlingen, 78532, Germany
Site Reference ID/Investigator# 57910
Ueberlingen-Nussdorf, 88662, Germany
Site Reference ID/Investigator# 33640
Ulm, 89073, Germany
Site Reference ID/Investigator# 33723
Ulm, 89073, Germany
Site Reference ID/Investigator# 81602
Unna, 59423, Germany
Site Reference ID/Investigator# 96241
Varel, 26316, Germany
Site Reference ID/Investigator# 98536
Verden an der Aller, 27283, Germany
Site Reference ID/Investigator# 72860
Viersen, 41749, Germany
Site Reference ID/Investigator# 33736
Villingen-Schwenningen, 78054, Germany
Site Reference ID/Investigator# 33741
Waltrop, 45731, Germany
Site Reference ID/Investigator# 53243
Wannsee, 14109, Germany
Site Reference ID/Investigator# 72853
Wasserburg, 83512, Germany
Site Reference ID/Investigator# 33748
Weener, 26826, Germany
Site Reference ID/Investigator# 33851
Welzow, 03119, Germany
Site Reference ID/Investigator# 35407
Wiesbaden, 65189, Germany
Site Reference ID/Investigator# 33764
Wiesbaden, 65191, Germany
Site Reference ID/Investigator# 52989
Wiesbaden, 65191, Germany
Site Reference ID/Investigator# 33771
Wilhelmshaven, 26382, Germany
Site Reference ID/Investigator# 53076
Winsen, 21423, Germany
Site Reference ID/Investigator# 33775
Wismar, 23966, Germany
Site Reference ID/Investigator# 33779
Wittlich, 54516, Germany
Site Reference ID/Investigator# 91095
Wittmund, 26409, Germany
Site Reference ID/Investigator# 96235
Wolfenbüttel, 38300, Germany
Site Reference ID/Investigator# 91068
Wuppertal, 42103, Germany
Site Reference ID/Investigator# 91069
Wuppertal, 42103, Germany
Site Reference ID/Investigator# 35419
Wuppertal, 42105, Germany
Site Reference ID/Investigator# 57884
Wurzen, 04808, Germany
Site Reference ID/Investigator# 33717
Würzburg, 97070, Germany
Site Reference ID/Investigator# 57903
Würzburg, 97070, Germany
Site Reference ID/Investigator# 53064
Zeitz, 06712, Germany
Site Reference ID/Investigator# 33863
Zerbst, 39261, Germany
Site Reference ID/Investigator# 33866
Zeven, 27404, Germany
Site Reference ID/Investigator# 64299
Zschopau, 9405, Germany
Site Reference ID/Investigator# 52996
Zwickau, 08056, Germany
Site Reference ID/Investigator# 33875
Zwickau, 08060, Germany
Site Reference ID/Investigator# 52993
Zwickau, 08060, Germany
Site Reference ID/Investigator# 53056
Zwickau, 08060, Germany
Site Reference ID/Investigator# 53102
Zwickau, 08060, Germany
Site Reference ID/Investigator# 52994
Zwickau, 08066, Germany
Site Reference ID/Investigator# 53226
Zwickau, 8058, Germany
Site Reference ID/Investigator# 53260
Zwickau, 8060, Germany
Site Reference ID/Investigator# 33879
Zwiesel, 94227, Germany
Related Publications (4)
Behrens F, Koehm M, Schwaneck EC, Schmalzing M, Wittig BM, Gnann H, Greger G, Tony HP, Burkhardt H. Addition or removal of concomitant methotrexate alters adalimumab effectiveness in rheumatoid arthritis but not psoriatic arthritis. Scand J Rheumatol. 2019 Sep;48(5):375-382. doi: 10.1080/03009742.2019.1600717. Epub 2019 Jul 16.
PMID: 31311386DERIVEDBehrens F, Koehm M, Schwaneck EC, Schmalzing M, Gnann H, Greger G, Tony HP, Burkhardt H. Minimal disease activity is a stable measure of therapeutic response in psoriatic arthritis patients receiving treatment with adalimumab. Rheumatology (Oxford). 2018 Nov 1;57(11):1938-1946. doi: 10.1093/rheumatology/key203.
PMID: 30010891DERIVEDBehrens F, Koehm M, Thaci D, Gnann H, Greger G, Maria Wittig B, Burkhardt H. Anti-citrullinated protein antibodies are linked to erosive disease in an observational study of patients with psoriatic arthritis. Rheumatology (Oxford). 2016 Oct;55(10):1791-5. doi: 10.1093/rheumatology/kew229. Epub 2016 Jun 21.
PMID: 27330166DERIVEDBehrens F, Koehm M, Arndt U, Wittig BM, Greger G, Thaci D, Scharbatke E, Tony HP, Burkhardt H. Does Concomitant Methotrexate with Adalimumab Influence Treatment Outcomes in Patients with Psoriatic Arthritis? Data from a Large Observational Study. J Rheumatol. 2016 Mar;43(3):632-9. doi: 10.3899/jrheum.141596. Epub 2015 Dec 15.
PMID: 26669916DERIVED
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Global Medical Services
- Organization
- AbbVie (prior sponsor, Abbott)
Study Officials
- STUDY DIRECTOR
Bianca Wittig, MD
Abbvie Deutschland GmbH & Co. KG, Medical Department
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 26, 2010
First Posted
April 27, 2010
Study Start
August 1, 2005
Primary Completion
December 1, 2013
Study Completion
December 1, 2013
Last Updated
December 30, 2014
Results First Posted
December 30, 2014
Record last verified: 2014-12