Long Term Effect of General Practitioner Education on Antibiotic Prescribing

NCT01107223 | Unknown DMC

• 1 other identifier: PAAIR2
• Study Type: interventional
• Target: 170
• Locations: 1 country
• Sites: 1

Brief Summary

Respiratory tract infections are the most common indication for antibiotic prescribing in primary care. Several studies have shown a strong relationship between antibiotic use and bacterial resistance. The aim of this trial was to assess the long-term effect of a continuous education program on general practitioners antibiotic prescribing behaviour. 170 physicians were included in this study. Physicians randomized in the education group attended a two days seminar focused on evidence-based guidelines on antibiotic use in respiratory tract infections. The intervention was limited at physicians level and did not target the patients.

Conditions

Respiratory Tract Infections

Keywords

Antibiotic; Prescribing behaviour; Guidelines; Respiratory tract infections; Non-antibiotic prescription

Outcome Measures

Primary Outcomes (2)

• Change in the percentage of prescriptions containing an antibiotic between control and intervention groups (seminar on the treatment of respiratory tract infections).

  All prescriptions written by all general practitioners enrolled in the study were extracted each year from the French National Health System database. All data were compared to 2004 (baseline). Education group GPs attended a two-day seminar presenting evidence-based guidelines on antibiotic prescription in respiratory tract infections. The change (compared to baseline) in the percentage of prescriptions containing an antibiotic (antibiotic prescription rates) was compared between control and intervention groups.

  Effect of the intervention 4 to 6 months after the educational training.

• Change in the cost of antibiotic prescription between control and intervention groups (seminar on the treatment of respiratory tract infections).

  All prescriptions written by all general practitioners enrolled in the study were extracted each year from the French National Health System database. All data were compared to 2004 (baseline). Education group GPs attended a two-day seminar presenting evidence-based guidelines on antibiotic prescription in respiratory tract infections. The change (compared to baseline) in the cost of antibiotic prescription was compared between control and intervention groups.

  Effect of the intervention 4 to 6 months after the educational training.

Secondary Outcomes (6)

• Long term antibiotic prescription rates

  Effect of the intervention 28 to 30 months after the educational training.

• Long term antibiotic cost.

  Effect of the intervention 28 to 30 months after the educational training.

• Symptomatic drug prescription rates

  Effect of the intervention 28 to 30 months after the educational training.

• Symptomatic drug cost.

  Effect of the intervention 28 to 30 months after the educational training.

• Effect of patient age.

  Effect of the intervention 28 to 30 months after the educational training.

Study Arms (2)

Training to antibiotic prescription

EXPERIMENTAL

Physicians randomized in the education group attended a two days seminar focussed on evidence-based guidelines on antibiotic use in respiratory tract infections.

Other: Experimental: Training to antibiotic prescription

control

PLACEBO COMPARATOR

Other: No education on antibiotic prescription rules.

Interventions

Experimental: Training to antibiotic prescription OTHER

GPs assigned to the intervention group attended a two days didactic educational meeting on evidence-based guidelines for diagnosis and treatment of acute respiratory tract infection.

Training to antibiotic prescription

No education on antibiotic prescription rules. OTHER

GPs assigned to control group received no specific recommendations on antibiotic prescription.

control

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• General practitioners practicing in three departments of the Parisian area in France
• General practitioners attending a two days didactic educational meeting on evidence-based guidelines for diagnosis and treatment of acute respiratory tract infection.

You may not qualify if:

• None

Sponsors & Collaborators

• Henri Mondor University Hospital: lead

Study Sites (1)

Henri Mondor Hospital, department of general practice

Créteil, 94000, France

Location

Related Publications (1)

• Ferrat E, Le Breton J, Guery E, Adeline F, Audureau E, Montagne O, Roudot-Thoraval F, Attali C, Le Corvoisier P, Renard V. Effects 4.5 years after an interactive GP educational seminar on antibiotic therapy for respiratory tract infections: a randomized controlled trial. Fam Pract. 2016 Apr;33(2):192-9. doi: 10.1093/fampra/cmv107. Epub 2016 Jan 21.

  PMID: 26797464 DERIVED

MeSH Terms

Conditions

Respiratory Tract Infections

Condition Hierarchy (Ancestors)

Infections; Respiratory Tract Diseases

Study Officials

• Clause Attali, MD

  Henri Mondor University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: March 4, 2010
• First Posted: April 20, 2010
• Study Start: September 1, 2004
• Primary Completion: April 1, 2009
• Study Completion: April 1, 2010
• Last Updated: April 20, 2010

Record last verified: 2010-02

Locations

FR (1)