NCT01106885

Brief Summary

Evaluation of telephone care management intervention designed to improve outcomes among depressed diabetes patients.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
339

participants targeted

Target at P75+ for not_applicable diabetes

Timeline
Completed

Started May 2005

Longer than P75 for not_applicable diabetes

Geographic Reach
1 country

3 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2005

Completed
4.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2009

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

April 15, 2010

Completed
5 days until next milestone

First Posted

Study publicly available on registry

April 20, 2010

Completed
12 months until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2011

Completed
Last Updated

April 28, 2015

Status Verified

April 1, 2015

Enrollment Period

4.4 years

First QC Date

April 15, 2010

Last Update Submit

April 24, 2015

Conditions

Keywords

DiabetesDepressionTelephone Care ManagementMedication Care Management (MCM)Cognitive Behavioral Therapy (CBT)

Outcome Measures

Primary Outcomes (2)

  • Participant HbA1c levels

    one year

  • Participant cardiovascular risk index

    one year

Secondary Outcomes (5)

  • Proximal intervention targets

    one year

  • Other self-care behaviors

    one year

  • Health-related quality of life

    one year

  • Treatment satisfaction

    one year

  • Resource use

    one year

Study Arms (2)

Enhanced Usual Care

NO INTERVENTION

Adult patients with diabetes and depression. * Report screening results * Notify PCP of screening results (optional per patient) * PCP referrals * Educational materials regarding diabetes, physical activity, and depression

Staged Care Management

EXPERIMENTAL

Adult patients with diabetes and depression

Behavioral: Medication Care Management (MCM)Behavioral: Cognitive-Behavioral Therapy (CBT)

Interventions

* Basic physical activity counseling * Notify PCP and facilitate initiation of antidepressants * Medication monitoring calls at 1, 2, 4, 6, 8, 10, and 12 weeks\* * 1/mo monitoring in continuation phase (mos. 4-12)\* * Report \& recommendations to PCP after each patient call * Note: \*average of 10 minutes of telephone time each (series is repeated if second antidepressant trial is needed)

Staged Care Management

* Notify PCP * CBT Manual * Weekly CBT focused counseling for 12 weeks\*\* * Monthly CBT in months 4-12\*\* * Behavioral physical activity counseling * Report \& recommendations to PCP after each patient call * Note: \*\*average of 50 minutes of telephone time each

Staged Care Management

Eligibility Criteria

Age21 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Active Diabetes (Type 1 \& 2)
  • Diagnosis of depression
  • Using hypoglycemic medications
  • At least 1 outpatient visit in last 12 months
  • At least 21 years old

You may not qualify if:

  • Limited life expectancy (heart failure/ on oxygen/ advanced stage cancer/ dialysis)
  • End stage renal disease
  • Lung cancer
  • Dementia
  • Bipolar
  • Schizophrenia
  • Can't speak English
  • Memory problems
  • Alcohol problems
  • Illegal drug use
  • Minimal depressive symptoms
  • Blood pressure 180/110 or higher
  • Problems with loss of consciousness
  • Can't walk 10 minutes on level surface
  • Not planning to get their care at study site
  • +3 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

VA Ann Arbor Healthcare System

Ann Arbor, Michigan, 48105, United States

Location

University of Michigan Health System

Ann Arbor, Michigan, 48109, United States

Location

Genesys Regional Medical Center

Grand Blanc, Michigan, 48439, United States

Location

Related Publications (1)

  • Piette JD, Valenstein M, Himle J, Duffy S, Torres T, Vogel M, Richardson C. Clinical complexity and the effectiveness of an intervention for depressed diabetes patients. Chronic Illn. 2011 Dec;7(4):267-78. doi: 10.1177/1742395311409259. Epub 2011 Aug 12.

MeSH Terms

Conditions

Diabetes MellitusDepression

Interventions

Cognitive Behavioral Therapy

Condition Hierarchy (Ancestors)

Glucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesBehavioral SymptomsBehavior

Intervention Hierarchy (Ancestors)

Behavior TherapyPsychotherapyBehavioral Disciplines and Activities

Study Officials

  • John D Piette, PhD

    VA Ann Arbor Healthcare System

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
VA Senior Research Career Scientist and Professor of Internal Medicine

Study Record Dates

First Submitted

April 15, 2010

First Posted

April 20, 2010

Study Start

May 1, 2005

Primary Completion

October 1, 2009

Study Completion

April 1, 2011

Last Updated

April 28, 2015

Record last verified: 2015-04

Locations