Genetics of Motor Learning

NCT01105845 | Terminated

• 2 other identifiers: 10009210-N-0092
• Study Type: observational
• Target: 5
• Locations: 1 country
• Sites: 1

Brief Summary

Background: \- New studies in human genetics have revealed information about genetic connections to memory and motor behavior. Researchers are interested in investigating the role of genetics in motor learning, in conjunction with related studies taking place in the Human Motor Control Section of the National Institute of Neurological Diseases and Stroke (NINDS). Participants in motor learning studies conducted at NINDS will be asked to provide blood samples for further evaluation. Objectives: \- To create a repository of blood samples from patients and healthy subjects who are participating in NINDS motor learning studies. Eligibility: \- Individuals between 18 and 100 years of age who are or will be participating in motor learning research studies at the National Institutes of Health. Design:

• Blood draws for genetic testing will usually be done on the same day as the motor learning study. Participants will provide one blood sample for research.
• No treatment will be provided under this study....

Conditions

Parkinson s Disease; Dystonic Disorders; Focal Dystonia; Movement Disorders

Keywords

Motor Learning; Genetic Analysis; BDNF; Parkinson Disease; Movement Disorders; Dystonia; Healthy Volunteer; HV

Outcome Measures

Primary Outcomes (1)

• Genetic polymorphism frequency (e.g. BNDF Va166Met) compared to measures of motor learning (e.g. reaction time or fMRI BOLD signal change)

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

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• Anyone aged 18-100 years and participating in a motor learning study at NIH is eligible to participate in this study.
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You may not qualify if:

• Anyone with impaired decisional capacity, inability to provide informed consent, or who is unable to safely give blood is not eligible to participate in this study.

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Brunoni AR, Lopes M, Fregni F. A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int J Neuropsychopharmacol. 2008 Dec;11(8):1169-80. doi: 10.1017/S1461145708009309. Epub 2008 Aug 28.

  PMID: 18752720 BACKGROUND

• Cheeran B, Talelli P, Mori F, Koch G, Suppa A, Edwards M, Houlden H, Bhatia K, Greenwood R, Rothwell JC. A common polymorphism in the brain-derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS. J Physiol. 2008 Dec 1;586(23):5717-25. doi: 10.1113/jphysiol.2008.159905. Epub 2008 Oct 9.

  PMID: 18845611 BACKGROUND

• Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger DR. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell. 2003 Jan 24;112(2):257-69. doi: 10.1016/s0092-8674(03)00035-7.

  PMID: 12553913 BACKGROUND

MeSH Terms

Conditions

Parkinson Disease; Dystonic Disorders; Movement Disorders; Dystonia

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Synucleinopathies; Neurodegenerative Diseases; Dyskinesias; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Mark Hallett, M.D.

  National Institute of Neurological Disorders and Stroke (NINDS)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 16, 2010
• First Posted: April 19, 2010
• Study Start: April 14, 2010
• Study Completion: December 21, 2015
• Last Updated: November 22, 2019

Record last verified: 2015-12-21

Locations

US (1)