Physiology of Weakness in Movement Disorders

NCT00307346 | Completed

• 2 other identifiers: 06012506-N-0125
• Study Type: observational
• Target: 6
• Locations: 1 country
• Sites: 1

Brief Summary

This study will compare electroencephalograph (EEG) recordings in healthy volunteers and in people with movement disorders to examine brain activity associated with the weakness. EEG records the electrical activity of the brain ("brain waves"). Healthy volunteers and patients with arm or leg weakness who are between 18 and 80 years of age may be eligible for this study. Healthy subjects are screened with a medical history, physical and neurological examinations, and a questionnaire. They must be right-handed and never have had a neurological disease or head trauma. All participants have an EEG. An elastic cap with electrodes is placed on the subject's scalp to record the brain's electrical activity. During the EEG, subjects are required to resist against a force with their arm, elbow, shoulder or leg for as long as they can. Several recordings are done with short breaks between them.

Conditions

Movement Disorders

Keywords

Movement-Related Potential; Electroencephalogram; Psychogenic Movement Disorders; Psychogenic Movement Disorder; Healthy Volunteer; HV

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Both patients and healthy volunteers will be between age 18 and 80.
• Patients will be evaluated in the Human Motor Control Clinic at NINDS.
• The definite diagnosis of the disease may not be completely established at the time of recording.
• Patients have clear and reproducible symptoms of give way weakness of either upper or lower extremities.
• Patients have to be able to resist against the examiner for at least two seconds before giving way.
• Healthy volunteers are right handed adults without history of neurological disease or severe head trauma.

You may not qualify if:

• Subjects (patients or volunteers) who cannot understand the instructions and consent forms of the protocol will be excluded.
• Subjects who cannot follow the instruction during the entire recording for whatever reason will be excluded.
• Patients with a documented organic central nervous system lesion may be excluded from the study. This will be discussed in detail for each individual subject at the Human Motor Control Clinic.

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Terada K, Ikeda A, Nagamine T, Shibasaki H. Movement-related cortical potentials associated with voluntary muscle relaxation. Electroencephalogr Clin Neurophysiol. 1995 Nov;95(5):335-45. doi: 10.1016/0013-4694(95)00098-j.

  PMID: 7489662 BACKGROUND

• Terada K, Ikeda A, Yazawa S, Nagamine T, Shibasaki H. Movement-related cortical potentials associated with voluntary relaxation of foot muscles. Clin Neurophysiol. 1999 Mar;110(3):397-403. doi: 10.1016/s1388-2457(98)00017-0.

  PMID: 10363761 BACKGROUND

• Toma K, Honda M, Hanakawa T, Okada T, Fukuyama H, Ikeda A, Nishizawa S, Konishi J, Shibasaki H. Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation: an event-related fMRI study. J Neurosci. 1999 May 1;19(9):3527-34. doi: 10.1523/JNEUROSCI.19-09-03527.1999.

  PMID: 10212312 BACKGROUND

MeSH Terms

Conditions

Movement Disorders

Condition Hierarchy (Ancestors)

Central Nervous System Diseases; Nervous System Diseases

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: March 24, 2006
• First Posted: March 27, 2006
• Study Start: March 23, 2006
• Study Completion: January 25, 2011
• Last Updated: July 2, 2017

Record last verified: 2011-01-25

Locations

US (1)