Dengue Seroprevalence Study in Blood Donors in the French West Indies

NCT01104740 | Completed

• 2 other identifiers: 10/B/012010-A00385-34
• Study Type: observational
• Target: 817
• Locations: 2 countries
• Sites: 2

Brief Summary

Dengue is an infectious disease most prevalent in the world. This disease is endemic in the Caribbean, with an increase in seasonal rains. Several outbreaks have been observed in recent years, in 2001, 2005 and 2007, during which further particularly virulent serotypes have emerged. The clinical expression of dengue fever is variable, ranging from no symptoms to a classical form with fever, and even of severe or lethal bleeding. With the possible existence of silent forms of the disease, there are no data identifying the current level of protection of the population in Martinique / Guadeloupe.

Conditions

Blood Donors; Dengue

Outcome Measures

Primary Outcomes (1)

• Presence or not of dengue virus-specific immunoglobulin G antibodies

  1 day

Secondary Outcomes (1)

• Characterization of dengue virus serotype-specific IgG

  1 day

Interventions

Biological sample collection OTHER

Blood (serum) sample collection

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult, résidents in Martinique/ Guadeloupe (french west indies), aged 18 to 65 years coming to give their blood in one of the building or mobile collection facilities of the French Blood Establishment in French West Indies.

You may qualify if:

• Eligible for blood donation following the French legislation,
• Resident in Martinique /Guadeloupe for at least one year
• Consent signed

You may not qualify if:

• Not Eligible for blood donation following the French legislation,
• Not Resident in Martinique / Guadeloupe for at least one year
• Consent not signed

Sponsors & Collaborators

• Etablissement Français du Sang, Martinique: lead
• Sanofi Pasteur, a Sanofi Company: collaborator
• Institut National de la Santé Et de la Recherche Médicale, France: collaborator
• Clinique Antilles-Guyane: collaborator

Study Sites (2)

French Blood Establishment of Guadeloupe

Pointe-à-Pitre, 97171, Guadeloupe

Location

French Blood Establishment of Martinique

Fort-de-France, 97264, Martinique

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum

MeSH Terms

Conditions

Dengue

Condition Hierarchy (Ancestors)

Mosquito-Borne Diseases; Vector Borne Diseases; Infections; Arbovirus Infections; Virus Diseases; Flavivirus Infections; Flaviviridae Infections; RNA Virus Infections; Hemorrhagic Fevers, Viral

Study Officials

• Pascale RICHARD, MD

  French Blood Establishment of Martinique

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Directrice EFS Martinique

Study Record Dates

• First Submitted: April 14, 2010
• First Posted: April 15, 2010
• Study Start: May 1, 2011
• Primary Completion: May 1, 2011
• Study Completion: May 1, 2012
• Last Updated: August 20, 2021

Record last verified: 2021-08

Locations

GU (1); MA (1)