NCT01101945

Brief Summary

The purpose of this study is to demonstrate that dutogliptin/PHX1149T is safe and tolerable.

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
339

participants targeted

Target at P75+ for phase_2 type-2-diabetes-mellitus

Timeline
Completed

Started Jul 2007

Longer than P75 for phase_2 type-2-diabetes-mellitus

Geographic Reach
5 countries

55 active sites

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2007

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2010

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2010

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

April 8, 2010

Completed
4 days until next milestone

First Posted

Study publicly available on registry

April 12, 2010

Completed
Last Updated

August 11, 2010

Status Verified

August 1, 2010

Enrollment Period

2.5 years

First QC Date

April 8, 2010

Last Update Submit

August 10, 2010

Conditions

Keywords

diabetesDPP4 inhibitordutogliptinPHX1149

Outcome Measures

Primary Outcomes (2)

  • To demonstrate safety and tolerability of dutogliptin/PHX1149T as assessed by vital signs, adverse event reporting, and routine clinical laboratory assessments

    104 weeks

  • To demonstrate safety and tolerability of dutogliptin/PHX1149Tas assessed by vital signs, adverse event reporting, and routine clinical laboratory assessments

    208 weeks (U.S. only)

Secondary Outcomes (1)

  • To demonstrate maintenance or lowering of HbA1c and fasting blood glucose

    104 weeks

Interventions

400 mg QD

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Completed Visit 7/Day 98 of the core protocol PHX1149-PROT202
  • Current treatment of Type 2 diabetes mellitus in accordance with product labeling with metformin, or thiazolidinedione (TZD), or metformin + TZD

You may not qualify if:

  • Inadequately controlled Type 2 diabetes mellitus with need for therapy with insulin

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (55)

Unknown Facility

Fullerton, California, United States

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Unknown Facility

Long Beach, California, United States

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Orange, California, United States

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San Diego, California, United States

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Kissimmee, Florida, United States

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Melbourne, Florida, United States

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Unknown Facility

New Port Richey, Florida, United States

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Unknown Facility

Gurnee, Illinois, United States

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Wichita, Kansas, United States

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Kansas City, Missouri, United States

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Henderson, Nevada, United States

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Las Vegas, Nevada, United States

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Berlin, New Jersey, United States

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Margate City, New Jersey, United States

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Trenton, New Jersey, United States

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Charlotte, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Cincinnati, Ohio, United States

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Oklahoma City, Oklahoma, United States

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Medford, Oregon, United States

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Warminster, Pennsylvania, United States

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Columbia, South Carolina, United States

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Greer, South Carolina, United States

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Dallas, Texas, United States

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San Antonio, Texas, United States

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Salt Lake City, Utah, United States

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Norfolk, Virginia, United States

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Cuidad Autonoma de Buenos Aires, Buenos Aires, Argentina

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La Plata, Buenos Aires, Argentina

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Lanús Este, Buenos Aires, Argentina

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Morón, Buenos Aires, Argentina

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Quilmes, Buenos Aires, Argentina

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Corrientes, Corrientes Province, Argentina

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Calgary, Alberta, Canada

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Red Deer, Alberta, Canada

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Mount Pearl, Newfoundland and Labrador, Canada

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Unknown Facility

St. John's, Newfoundland and Labrador, Canada

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Unknown Facility

Etobicoke, Ontario, Canada

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London, Ontario, Canada

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Samia, Ontario, Canada

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Toronto, Ontario, Canada

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Cornwall, Prince Edward Island, Canada

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Mirabel, Quebec, Canada

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Montreal, Quebec, Canada

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Unknown Facility

Ellisbridge, Ahmedabad, India

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Banjara Hills, Hyderabad, India

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Punjagutta, Hyderabad, India

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Pune, Maharashtra, India

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Tardeo, Mumbai, India

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Dhantoli, Nagpur, India

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Unknown Facility

Chennai, Tamil Nadu, India

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Unknown Facility

Guadalajara, Jalisco, Mexico

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Unknown Facility

Mexico City, Mexico City, Mexico

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Unknown Facility

Morelia, Michoacán, Mexico

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Unknown Facility

Monterrey N. L., Nuevo León, Mexico

Location

MeSH Terms

Conditions

Diabetes Mellitus, Type 2Diabetes Mellitus

Interventions

dutogliptin

Condition Hierarchy (Ancestors)

Glucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Design

Study Type
interventional
Phase
phase 2
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

April 8, 2010

First Posted

April 12, 2010

Study Start

July 1, 2007

Primary Completion

January 1, 2010

Study Completion

March 1, 2010

Last Updated

August 11, 2010

Record last verified: 2010-08

Locations