NCT01100840

Brief Summary

The purpose of this study is:

  1. 1.To characterize the types and frequency of molecular alterations to the epidermal growth factor receptor (EGFR) pathway, FGFR4 and EML-ALK in Asian patients with non-small cell lung cancer
  2. 2.To identify candidate biomarkers of importance in the EGFR and estrogen pathways

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2009

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

September 14, 2009

Completed
7 months until next milestone

First Posted

Study publicly available on registry

April 9, 2010

Completed
4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2014

Completed
Last Updated

December 11, 2013

Status Verified

December 1, 2013

Enrollment Period

5 years

First QC Date

September 14, 2009

Last Update Submit

December 10, 2013

Conditions

Non Small Cell Lung Cancer

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Archived paraffin-embedded and fresh frozen NSCLC tumor tissue will be obtained via the Department of Pathology at Tan Tock Seng Hospital and National University Hospital and the National University Tissue Repository respectively. Clinico-pathological characteristics will be obtained from the case records, Pathology and Tissue Repository.

You may qualify if:

  • Nil

You may not qualify if:

  • Nil

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National University Hospital

Singapore, Singapore, 119074, Singapore

RECRUITING

Related Publications (2)

  • Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med. 2004 Aug;10(8):789-99. doi: 10.1038/nm1087.

    PMID: 15286780BACKGROUND

  • Ciardiello F, Tortora G. A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor. Clin Cancer Res. 2001 Oct;7(10):2958-70.

    PMID: 11595683BACKGROUND

MeSH Terms

Conditions

Carcinoma, Non-Small-Cell Lung

Condition Hierarchy (Ancestors)

Carcinoma, BronchogenicBronchial NeoplasmsLung NeoplasmsRespiratory Tract NeoplasmsThoracic NeoplasmsNeoplasms by SiteNeoplasmsLung DiseasesRespiratory Tract Diseases

Study Officials

  • Ross Andrew Soo, MBBS

    National University Hospital, Singapore

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Ross Andrew Soo, MBBS

CONTACT

65 67724624ross_soo@nuhs.edu.sg

Study Design

Study Type
observational
Observational Model
CASE CROSSOVER
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER

Study Record Dates

First Submitted

September 14, 2009

First Posted

April 9, 2010

Study Start

April 1, 2009

Primary Completion

April 1, 2014

Last Updated

December 11, 2013

Record last verified: 2013-12

Locations

SG(1)