Troponin T as Risk Stratification Tool in Peripheral Arterial Occlusive Disease
1 other identifier
observational
1,000
1 country
1
Brief Summary
Study hypothesis: elevated Troponin T is a marker of increased mortality in patients with peripheral arterial occlusive disease (PAOD).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2010
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2010
CompletedFirst Submitted
Initial submission to the registry
March 15, 2010
CompletedFirst Posted
Study publicly available on registry
March 16, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2011
CompletedApril 15, 2015
April 1, 2015
1.8 years
March 15, 2010
April 14, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Death
1 year
Secondary Outcomes (1)
Myocardial infarction, acute coronary syndrome, percutaneous coronary intervention, stroke, amputation, peripheral revascularization, target limb revascularization, target vessel revascularization
1 year
Study Arms (2)
Troponin T elevation
No troponin T elevation
Eligibility Criteria
patients with peripheral arterial occlusive disease (Fontaine stages II-IV)
You may qualify if:
- symptomatic peripheral arterial occlusive disease
- aged \>/= 18 years
You may not qualify if:
- unstable angina or acute coronary syndrome \< 14 days
- percutaneous coronary intervention \< 14 days
- other interventions or disease associated with troponin T release (i.e., acute pulmonary embolism, aortic dissection, heart valve replacement, acute heart failure, non-ischemic cardiomyopathy, heart surgery, thoracic trauma, endocarditis, myocarditis
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Angiologie, Herzzentrum Bad Krozingen
Bad Krozingen, D-79189, Germany
Related Publications (2)
Linnemann B, Sutter T, Herrmann E, Sixt S, Rastan A, Schwarzwaelder U, Noory E, Buergelin K, Beschorner U, Zeller T. Elevated cardiac troponin T is associated with higher mortality and amputation rates in patients with peripheral arterial disease. J Am Coll Cardiol. 2014 Apr 22;63(15):1529-38. doi: 10.1016/j.jacc.2013.05.059. Epub 2013 Jun 21.
PMID: 23792625DERIVEDLinnemann B, Sutter T, Sixt S, Rastan A, Schwarzwaelder U, Noory E, Buergelin K, Beschorner U, Zeller T. Elevated cardiac troponin T contributes to prediction of worse in-hospital outcomes after endovascular therapy for acute limb ischemia. J Vasc Surg. 2012 Mar;55(3):721-9. doi: 10.1016/j.jvs.2011.10.024. Epub 2012 Jan 24.
PMID: 22277685DERIVED
MeSH Terms
Conditions
Study Officials
- PRINCIPAL INVESTIGATOR
Birgit Linnemann, M.D.
Heart Center Bad Krozingen, Germany
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr. Birgit Linnemann
Study Record Dates
First Submitted
March 15, 2010
First Posted
March 16, 2010
Study Start
March 1, 2010
Primary Completion
December 1, 2011
Study Completion
December 1, 2011
Last Updated
April 15, 2015
Record last verified: 2015-04