Intrabronchial Airway Pressures in Intubated Patients During Bronchoscopy

NCT01078831 | Completed

• 1 other identifier: REK-HO Ref 191-01055, 03052001
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine changes in ventilation and airway pressures during conventional bronchoscopy of intubated patients.

Conditions

Acute Respiratory Distress Syndrome; Acute Lung Injury (ALI)

Outcome Measures

Primary Outcomes (1)

• Changes in ventilation, airway pressures and blood gases after bronchoscope insertion.

  paO2, paCO2 (kPa), airway and ventilator pressures (cmH2O)

  2 minutes after bronchoscope insertion/ mode change

Study Arms (1)

ARDS / ALI patients

Other: Bronchoscopy

Interventions

Bronchoscopy OTHER

Airway pressures, ventilation changes and blood gas changes are recorded in a group of intubated patients on mechanical ventilation before and after bronchoscope insertion. The registration is done immediately before a therapeutic/diagnostic bronchoscopy requested by a staff physician not involved n the study.

ARDS / ALI patients

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

ARDS/ALI patients on mechanical ventilation where a therapeutic or diagnostic bronchoscopy has been requested by the staff physician.

You may qualify if:

• ARDS/ALI patients on mechanical ventilation
• endotracheal tube size 7-9mm
• age \> 18 years
• therapeutic or diagnostic bronchoscopy requested by staff physician

You may not qualify if:

• SpO2 \< 90%
• unstable BP
• pneumothorax
• acute cardiovascular disease
• cerebrovascular or other condition that requires stable BP and saturation

Sponsors & Collaborators

• Oslo University Hospital: lead

Study Sites (1)

Oslo University Hospital - Ulleval

Oslo, Oslo County, 0407, Norway

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Arterial blood gases

MeSH Terms

Conditions

Respiratory Distress Syndrome; Acute Lung Injury

Interventions

Bronchoscopy

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Respiration Disorders; Lung Injury

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Respiratory System; Diagnostic Techniques and Procedures; Diagnosis; Endoscopy; Diagnostic Techniques, Surgical; Minimally Invasive Surgical Procedures; Surgical Procedures, Operative; Pulmonary Surgical Procedures; Thoracic Surgical Procedures

Study Officials

• Helge Opdahl, MD, PhD

  Oslo University Hospital - Ulleval, Norway

  STUDY DIRECTOR

• Ole H Skjønsberg, MD, PhD

  Ullevaal University Hospital

  STUDY DIRECTOR

• Fredrik Borchsenius, MD

  Ullevaal University Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: March 1, 2010
• First Posted: March 2, 2010
• Study Start: March 1, 2002
• Primary Completion: April 1, 2010
• Study Completion: April 1, 2010
• Last Updated: November 11, 2010

Record last verified: 2010-11

Locations

NO (1)