The Effects of the Endocrine System on Endometrial Cancer

NCT01075386 | Completed

• 1 other identifier: Endo01
• Study Type: observational
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

Endometrial cancer usually begins in the endometrium, which is the tissue lining of the uterus. Endometrial cancer is the most commonly diagnosed gynaecological malignancy in Australia. It affects 1 in 80 Australian women and there are about 1400 new cases and 260 deaths from the disease every year. Most affected women are aged between 50 and 70 years. The purpose of this study is to investigate the possible role of the endocrine system in the regulation of human endometrial cancer. By looking at the laboratory results of people with endometrial cancer and also those without endometrial cancer we hope to gain a better understanding of how endometrial cancer develops and progresses. This may lead to the development of new, effective therapies for endometrial cancer.

Conditions

Endometrial Cancer

Keywords

Hysterectomy; Endometrial cancer; Benign; Endocrine system; Tissue collection

Study Arms (4)

Grade 2

Patients with Endometrial cancer of Grade 1 differentiation

Benign

Patients without endometrial cancer

Grade 1

Patients with Endometrial cancer of Grade 2 differentiation

Grade 3

Patients with Endometrial cancer of Grade 3 differentiation

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with endometrial cancer and patients who are having a hysterectomy for non-cancerous conditions such as fibroids, chronic pelvis pain or abnormal uterine bleeding are eligible for the study

You may qualify if:

• women aged 18 years or older
• having a hysterectomy for the treatment of endometrial cancer, fibroids, chronic pelvic pain or abnormal uterine bleeding
• have provided informed consent

Sponsors & Collaborators

• Queensland Centre for Gynaecological Cancer: lead
• Greenslopes Private Hospital: collaborator
• The University of Queensland: collaborator
• Sullivan Nicolaides Pathology: collaborator

Study Sites (1)

Greenslopes Private Hospital

Greenslopes, Queensland, 4120, Australia

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Endometrial tissue

MeSH Terms

Conditions

Endometrial Neoplasms

Condition Hierarchy (Ancestors)

Uterine Neoplasms; Genital Neoplasms, Female; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Uterine Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases

Study Officials

• Chen Chen, MD PhD

  The University of Queensland

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 23, 2010
• First Posted: February 25, 2010
• Study Start: October 1, 2009
• Primary Completion: August 1, 2011
• Study Completion: December 1, 2018
• Last Updated: August 28, 2019

Record last verified: 2019-08

Locations

AU (1)